Document Detail

Changes in lung function in young cystic fibrosis patients between two courses of intravenous antibiotics against Pseudomonas aeruginosa.
MedLine Citation:
PMID:  19360849     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIMS: Repeated intravenous antibiotic therapy (IVAT) against chronic pulmonary infection with Pseudomonas aeruginosa is often necessary in cystic fibrosis patients (CF). The aim of this study was to monitor kinetics of degradation of pulmonary and nutritional status after IVAT in CF patients. METHODS: Lung function, nutritional status and physical activity (PA) were measured for 21 CF patients (mean +/- SD age, 16 +/- 1.9 years; 9 boys) who were chronically colonized by P. aeruginosa. Each parameter was measured every 15 days during 3-6 months. RESULTS: Nutritional status as well as PA did not change in the interval of 2 IVAT. In contrary, lung function worsened with a decrease of -14.6% of the FEV(1) (P < 0.05). CONCLUSION: In CF, there is a progressive decrease in lung function without any evident deterioration of nutritional status and PA between two IVAT.
Laurent Béghin; Laurent Michaud; Guy-André Loeuille; Nathalie Wizla-Derambure; Hocine Sayah; Anne Sardet; Caroline Thumerelle; Antoine Deschildre; Dominique Turck; Frédéric Gottrand
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric pulmonology     Volume:  44     ISSN:  1099-0496     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-27     Completed Date:  2009-08-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  464-71     Citation Subset:  IM    
Copyright Information:
(c) 2009 Wiley-Liss, Inc.
EA 3925, Université Lille 2 Droit et Santé & Division of Gastroenterology, Hepatology and Nutrition, Cystic Fibrosis Center, Lille, France.
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MeSH Terms
Anti-Bacterial Agents / administration & dosage*
Cystic Fibrosis / microbiology,  physiopathology*
Drug Administration Schedule
Infusions, Intravenous
Lung / physiopathology*
Nutritional Status*
Prospective Studies
Pseudomonas Infections / complications,  drug therapy*
Respiratory Function Tests
Respiratory Tract Infections / complications,  drug therapy*,  microbiology
Young Adult
Reg. No./Substance:
0/Anti-Bacterial Agents

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