Document Detail

Changes in liver gluconeogenesis during the development of Walker-256 tumour in rats.
MedLine Citation:
PMID:  23317353     Owner:  NLM     Status:  MEDLINE    
Few studies have investigated liver gluconeogenesis in cancer and there is no agreement as to whether the activity of this pathway is increased or decreased in this disease. The aim of this study was to evaluate gluconeogenesis from alanine, pyruvate and glycerol, and related metabolic parameters in perfused liver from Walker-256 tumour-bearing rats on days 5 (WK5 group), 8 (WK8 group) and 12 (WK12 group) of tumour development. There was reduction (P < 0.05) of liver glucose production from alanine and pyruvate in WK5, WK8 and WK12 groups, which was accompanied by a decrease (P < 0.05) in oxygen consumption. Moreover, there was higher (P < 0.05) pyruvate and lactate production from alanine in the WK5 group and a marked reduction (P < 0.05) of pyruvate and urea production from alanine in the WK12 group. In addition, liver glucose production and oxygen consumption from glycerol were not reduced in WK5, WK8 and WK12 groups. Thus the, the results show inhibition of hepatic gluconeogenesis from alanine and pyruvate, but not from glycerol, on days 5, 8 and 12 of Walker-256 tumour development, which can be attributed to the metabolic step in which the substrate enters the gluconeogenic pathway.
Carolina Campos Lima Moreira; Priscila Cassolla; Ana Paula Segantini Dornellas; Hely de Morais; Camila Oliveira de Souza; Glaucia Regina Borba-Murad; Roberto Barbosa Bazotte; Helenir Medri de Souza
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of experimental pathology     Volume:  94     ISSN:  1365-2613     ISO Abbreviation:  Int J Exp Pathol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-15     Completed Date:  2013-03-05     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9014042     Medline TA:  Int J Exp Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  47-55     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. International Journal of Experimental Pathology © 2012 International Journal of Experimental Pathology.
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MeSH Terms
Alanine / metabolism
Carcinoma 256, Walker / metabolism*,  pathology
Cell Proliferation
Glucose / metabolism*
Glycerol / metabolism
Liver / metabolism*
Oxygen Consumption
Pyruvic Acid / metabolism
Rats, Wistar
Soft Tissue Neoplasms / metabolism*,  pathology
Time Factors
Tumor Burden
Urea / metabolism
Reg. No./Substance:
8558G7RUTR/Pyruvic Acid; 8W8T17847W/Urea; IY9XDZ35W2/Glucose; OF5P57N2ZX/Alanine; PDC6A3C0OX/Glycerol

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