Document Detail


Changes in liver function tests after propofol ('Diprivan').
MedLine Citation:
PMID:  3877286     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Changes in three recognized liver function tests are reported following the use of propofol in 30 fit, unpremedicated women in whom propofol was used as the main anaesthetic agent. Doses of 140 to 330 mg were given, together with nitrous oxide and oxygen. All patients were undergoing minor gynaecological operations and all conformed to Grade 1 physical status of American Society of Anesthesiologists Classification. In none of these patients was there hypoxia or hypercarbia at any time during or following anaesthesia and none of the patients received any other drugs until completion of the study. No significant changes in liver enzymes (aspartate transaminase and alanine transaminase) or in serum alkaline phosphatase were detected.
Authors:
F P Robinson; C C Patterson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  61 Suppl 3     ISSN:  0032-5473     ISO Abbreviation:  Postgrad Med J     Publication Date:  1985  
Date Detail:
Created Date:  1985-12-16     Completed Date:  1985-12-16     Revised Date:  2009-10-22    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  160-1     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anesthesia, Intravenous*
Female
Humans
Liver / drug effects*,  enzymology
Liver Function Tests
Middle Aged
Phenols* / adverse effects
Propofol
Chemical
Reg. No./Substance:
0/Phenols; 2078-54-8/Propofol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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