Document Detail

Changes in liver function parameters after occlusion of gastrorenal shunts with balloon-occluded retrograde transvenous obliteration.
MedLine Citation:
PMID:  9177524     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE AND METHODS: To evaluate the effects of portal blood flow on liver function, this pilot study investigated the correlation between changes in portal blood flow as measured by image-directed Doppler ultrasonography and liver function tests in nine patients with cirrhosis who were treated with balloon-occluded retrograde transvenous obliteration. All patients had large gastric varices and prominent gastrorenal shunts. RESULTS: Treatment caused a significant increase (p < 0.01) in portal blood flow; we documented reversion from hepatofugal to hepatopetal portal flow in one patient and increases in hepatopetal flow from 5.4 +/- 1.1 to 7.85 +/- 1.4 cm/s (mean +/- SD) in eight patients. All patients showed decreases in gastric variceal size. However, portal pressure rose significantly in all patients after treatment from 25.4 +/- 7.6 to 30.7 +/- 5.8 mmH2O (n = 7, mean +/- SD), and two of nine patients had worsening of esophageal varices. All nine patients showed improvement in the 15-min retention rate of indocyanine green from 31.8 +/- 16.1 to 21.8 +/- 12.4% (mean +/- SD, p < 0.01), whereas seven patients showed increased serum albumin levels after treatment. CONCLUSIONS: These results suggest balloon-occluded retrograde transvenous obliteration increases hepatic portal blood flow, which may be accompanied by improvements in liver function.
T Akahane; T Iwasaki; N Kobayashi; N Tanabe; N Takahashi; H Gama; M Ishii; T Toyota
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  92     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-07-03     Completed Date:  1997-07-03     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1026-30     Citation Subset:  IM    
Third Department of Internal Medicine, Tohoku University School of Medicine, Aoba-ku, Sendai, Japan.
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MeSH Terms
Blood Flow Velocity
Collateral Circulation*
Coloring Agents / diagnostic use
Contrast Media
Esophageal and Gastric Varices / blood,  physiopathology,  therapy*,  ultrasonography
Follow-Up Studies
Indocyanine Green / diagnostic use
Kidney / blood supply
Liver / physiopathology*,  ultrasonography
Liver Circulation*
Liver Cirrhosis / blood,  complications,  physiopathology
Middle Aged
Oleic Acids / therapeutic use
Pilot Projects
Portal Pressure
Portal System / physiopathology,  ultrasonography
Sclerosing Solutions / therapeutic use
Sclerotherapy / methods*
Serum Albumin / analysis
Stomach / blood supply
Ultrasonography, Doppler
Reg. No./Substance:
0/Coloring Agents; 0/Contrast Media; 0/Oleic Acids; 0/Sclerosing Solutions; 0/Serum Albumin; 3282-75-5/ethanolamine oleate; 3599-32-4/Indocyanine Green; 62883-00-5/Iopamidol

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