| Changes in lipoprotein profile and urinary albumin excretion in familial LCAT deficiency with lipid lowering therapy. | |
| | |
MedLine Citation:
|
PMID: 19230892 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Familial lecithin:cholesterol acyltransferase deficiency (FLD) is a monogenic autosomal recessive condition, affecting cholesterol esterification and leads to progressive renal impairment and end-stage renal failure, probably due to the abnormal lipoprotein (X) (Lp(X)). We report a case of FLD, whom we treated with a combination of nicotinic acid 1.5g nocte and fenofibrate M/R 160mg od and report changes in lipid profile and Lp(X), after six weeks and serum creatinine and urine albumin/creatinine ratio after 12 months. We assessed the cardiovascular risk using electron beam computed tomography. At baseline total cholesterol was 6.61mmol/L; HDL cholesterol 0.57mmol/L; Lp(X) cholesterol 3.24mmol/L; triglyceride 4.13mmol/L; apolipoprotein A1 46mg/dL; and apolipoprotein B 53mg/dL. After six weeks of treatment his total cholesterol was 4.16; HDL cholesterol 0.52; Lp(X) cholesterol 1.73mmol/L; triglyceride 1.80mmol/L; apolipoprotein A1 36mg/dL; and apolipoprotein B 50mg/dL. Baseline serum creatinine was 106micromol/L and urine albumin/creatinine ratio was 127.3mg/mmol and after 12 months was 101micromol/L and 31.5mg/mmol respectively. His coronary artery calcification score was zero. We have shown, we believe for the first time, that combination lipid modifying therapy in FLD leads to a reduction in Lp(X) concentration and an associated reduction in urine albumin excretion at 12 months. |
| | |
Authors:
|
Michael S Yee; Darrell V Pavitt; William Richmond; H Terence Cook; Adam G McLean; Jonathan Valabhji; Robert S Elkeles |
Publication Detail:
|
Type: Case Reports; Journal Article Date: 2009-01-29 |
Journal Detail:
|
Title: Atherosclerosis Volume: 205 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2009 Aug |
Date Detail:
|
Created Date: 2009-07-28 Completed Date: 2009-12-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
|
Languages: eng Pagination: 528-32 Citation Subset: IM |
Affiliation:
|
Imperial College London, St Mary's Hospital, London, UK. m.yee@imperial.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Albumins / analysis* Antilipemic Agents / therapeutic use Calcium / metabolism Cholesterol / metabolism Coronary Vessels / pathology Humans Lecithin Acyltransferase Deficiency / blood*, genetics*, urine* Lipoprotein-X / metabolism Lipoproteins / blood* Male Niacin / pharmacology Procetofen / pharmacology Tomography, X-Ray Computed / methods Triglycerides / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Albumins; 0/Antilipemic Agents; 0/Lipoprotein-X; 0/Lipoproteins; 0/Triglycerides; 49562-28-9/Procetofen; 57-88-5/Cholesterol; 59-67-6/Niacin; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Leukocyte telomere length is associated with HDL cholesterol levels: The Bogalusa heart study.
Next Document: Relationship between low lymphocyte count and major cardiac events in patients with acute chest pain...