Document Detail


Changes in lipids containing long- and very long-chain polyunsaturated fatty acids in cryptorchid rat testes.
MedLine Citation:
PMID:  17429018     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study was to examine the effects of experimental cryptorchidism on rat testicular phospholipids and neutral lipids that contain long-chain (C(18)-C(22)) and very long-chain (VLC) (C(24)-C(32)) polyunsaturated fatty acids (PUFA). The weight of the cryptorchid testis was nearly half that of the contralateral control at postsurgical Days 7-10 owing to the depletion of germ cells. Concomitantly, the amounts of major glycerophospholipids (GPL) and sphingomyelin (SM) per testis decreased. Both these lipids lost their characteristic long-chain and very long-chain PUFA, notably 22:5n-6 and 28:4n-6, respectively, which suggests that these species are linked to the membranes of germ cells. In contrast, the amounts and concentrations of triglycerides (TG; triacylglycerols and 1-O-alkyl-2,3-diacylglycerols) and cholesterol esters (CE) increased several fold in the surviving cells (mainly Sertoli cells) in the cryptorchid testis. All these neutral lipids, but especially CE, accumulated large amounts of the major PUFA of the testis, 22:5n-6, as well as pentaenes with longer carbon chains (i.e., 24:5n-6 in TG and 28:5n-6 in CE). This accretion suggests that neutral lipids may store preformed PUFA coming from dying germ cell GPL and also VLCPUFA no longer needed as a source of PUFA destined to assemble new germ cell GPL. The lipid adjustments observed in cryptorchidism suggest a possible role for Sertoli cell CE in the turnover and conservation of PUFA within seminiferous tubules.
Authors:
Natalia E Furland; Eduardo N Maldonado; Pablo Ayuza Aresti; Marta I Aveldaño
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-04-11
Journal Detail:
Title:  Biology of reproduction     Volume:  77     ISSN:  0006-3363     ISO Abbreviation:  Biol. Reprod.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-21     Completed Date:  2007-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207224     Medline TA:  Biol Reprod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  181-8     Citation Subset:  IM    
Affiliation:
Institute for Biochemical Research of Bahía Blanca, National Research Council and University of the South, 8000-Bahía Blanca, Argentina. nfurland@criba.edu.ar
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MeSH Terms
Descriptor/Qualifier:
Animals
Cryptorchidism / metabolism*
Fatty Acids, Unsaturated / chemistry*,  metabolism*
Germ Cells / metabolism
Male
Phospholipids / metabolism
Rats
Rats, Wistar
Testis / metabolism*
Chemical
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 0/Phospholipids

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