| Changes in lipid metabolism in postmenopausal Japanese women using hormone therapy evaluated by capillary isotachophoresis: a pilot study. | |
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MedLine Citation:
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PMID: 17603392 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of this study was to clarify the changes in lipid metabolism in postmenopausal Japanese women during continuous combined hormone therapy (HT) in detail by using capillary isotachophoresis (cITP). DESIGN: Twenty-three postmenopausal Japanese women with climacteric symptoms were recruited. Blood samples were collected from all participants before HT and after 3 and 6 months of HT, and changes in total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and apolipoprotein (apo) A-I, apoB, and lipoprotein(a) were assessed. The same blood samples were analyzed for charge-based lipoprotein subfractions using cITP. RESULTS: Total cholesterol (-8.5%), LDL-cholesterol (-16.2%), and lipoprotein(a) (-25.5%) decreased and apoA-I (9.5%) increased significantly from the baseline level at 6 months after starting continuous combined HT. HDL-cholesterol increased nonsignificantly (+2.4%). cITP revealed that the fast HDL subfraction (+24.7%), which contains apoA-I and may be antiatherogenic, significantly increased. Conversely, the fast LDL subfraction (+14.4%), which may possess atherogenic potential, increased during HT. CONCLUSIONS: The changes in lipid metabolism in postmenopausal Japanese women receiving HT are inconclusive regarding atherogenicity, ie, it increased fast HDL and simultaneously increased fast LDL. cITP is useful for clarifying the changes in lipid metabolism during HT. |
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Authors:
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Yoshihito Inoue; Bo Zhang; Riko Sadamori; Kyoko Shirota; Keijiro Saku; Tatsuhiko Kawarabayashi |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Menopause (New York, N.Y.) Volume: 15 ISSN: 1072-3714 ISO Abbreviation: Menopause Publication Date: 2008 Jan-Feb |
Date Detail:
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Created Date: 2008-01-11 Completed Date: 2008-05-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9433353 Medline TA: Menopause Country: United States |
Other Details:
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Languages: eng Pagination: 157-63 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Fukuoka University School of Medicine, Fukuoka, Japan. zenjin@fukuoka-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Apolipoproteins A
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blood Apolipoproteins B / blood Cholesterol / blood Cholesterol, HDL / blood Cholesterol, LDL / blood Electrophoresis, Capillary Estrogen Replacement Therapy / methods* Estrogens / administration & dosage* Female Humans Japan Lipoproteins / blood*, drug effects* Middle Aged Pilot Projects Postmenopause / blood* Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins A; 0/Apolipoproteins B; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Estrogens; 0/Lipoproteins; 0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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