Document Detail

Changes in the level of 7 alpha-hydroxy-3-oxo-4-cholestenoic acid in cerebrospinal fluid after subarachnoid hemorrhage.
MedLine Citation:
PMID:  7623950     Owner:  NLM     Status:  MEDLINE    
A high concentration of a type of cholic acid, 7 alpha-hydroxy-3-oxo-4-cholestenoic acid, is observed in the content of chronic subdural hematoma. To investigate the possible causes, the level of this compound was measured in the cerebrospinal fluid of patients who underwent surgery for aneurysmal subarachnoid hemorrhage or non-hemorrhagic diseases. The maximum level was significantly higher in the aneurysmal subarachnoid hemorrhage patients, indicating that surgical intervention did not cause the postoperative increase in the level of this compound in the cerebrospinal fluid. Monitoring of plasma levels showed no postoperative increase. In vitro culture of a mixture of arterial blood and cerebrospinal fluid failed to show the de novo production of this compound. These results strongly suggest extrahepatic intracranial production of this cholic acid occurs in subarachnoid hemorrhage. The high concentration of this compound in both chronic subdural hematoma and subarachnoid hemorrhage suggests a possible role for 7 alpha-hydroxy-3-oxo-4-cholestenoic acid in intracranial hemorrhagic disorders.
K Nagata; Y Seyama; T Shimizu
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurologia medico-chirurgica     Volume:  35     ISSN:  0470-8105     ISO Abbreviation:  Neurol. Med. Chir. (Tokyo)     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-08-31     Completed Date:  1995-08-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0400775     Medline TA:  Neurol Med Chir (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  294-7     Citation Subset:  IM    
Department of Neurosurgery, Showa General Hospital, Tokyo.
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MeSH Terms
Cholestenones / cerebrospinal fluid*
Hematoma, Subdural / cerebrospinal fluid,  surgery
Intracranial Aneurysm / cerebrospinal fluid*,  surgery
Middle Aged
Reference Values
Subarachnoid Hemorrhage / cerebrospinal fluid*,  surgery
Reg. No./Substance:
0/Cholestenones; 115538-85-7/7 alpha-hydroxy-3-oxo-4-cholestenoic acid

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