| Changes in left ventricular mass and filling after renal transplantation are related to changes in blood pressure: an echocardiographic and pulsed Doppler study. | |
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MedLine Citation:
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PMID: 7850816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To examine changes in left ventricular (LV) mass and function (diastolic and systolic) after successful renal allograft transplantation (RT), we prospectively studied 30 patients (19 men, 11 women, aged 37 +/- 13 years) by M-mode, two-dimensional and pulsed Doppler echocardiography at the time of surgery and 10 +/- 1.8 months later. At the time of transplantation all patients had been undergoing dialysis (4 peritoneal dialysis, 26 hemodialysis) for 2.5 +/- 3.2 years. A hematocrit of < or = 30% was present in 26 patients. After RT the mean hematocrit increased from 26 +/- 4 to 40 +/- 7 (p < 0.01), whereas systolic, diastolic and mean blood pressure (BP) remained unchanged. The LV mass index (LVMI) decreased from 201 +/- 56 to 171 +/- 41 g/m2, (p < 0.01); LV diastolic diameter corrected by body surface area (LVDDI) decreased from 298 +/- 38 to 279 +/- 35 (p < 0.01) and the LV end-diastolic volume index (LVEDVI) from 72 +/- 18 to 63 +/- 15 (p < 0.01). There were no changes in LV fractional shortening or LV end systolic wall stress. Peak late transmitral velocity (A wave) decreased from 77 +/- 16 to 68 +/- 12 cm/s (p < 0.01) with no changes in other Doppler-derived indexes of diastolic function. No fistula patency influence on changes in LV mass and function was found. After RT, BP decreased in 21 patients from 150 +/- 20 to 132 +/- 15 (p < 0.001; group I) and increased in 9 patients from 130 +/- 14 to 153 +/- 16 (p < 0.05, group II). Patients in group I suffered a reduction in LVMI (p < 0.001), LV end-diastolic diameter (p < 0.05), LVDDI (p < 0.001); LV end-diastolic volume (p < 0.05); LVEDVI (p < 0.01); cardiac index (p < 0.05), and peak late transmitral velocity (p < 0.01), but no changes in group-II patients were observed. We concluded that BP is a major determining factor with regard to changes in LV hypertrophy and function following RT. LV mass and volumes can be expected to decrease after RT in patients with BP reduction. |
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Authors:
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J Peteiro; N Alvarez; R Calviño; M Penas; F Ribera; A Castro Beiras |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Cardiology Volume: 85 ISSN: 0008-6312 ISO Abbreviation: Cardiology Publication Date: 1994 |
Date Detail:
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Created Date: 1995-03-13 Completed Date: 1995-03-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1266406 Medline TA: Cardiology Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 273-83 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Juan Canalejo Hospital, A Coruña, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Flow Velocity Blood Glucose / analysis Blood Pressure / physiology* Creatinine / blood Echocardiography, Doppler, Pulsed Female Follow-Up Studies Heart Rate Hematocrit Humans Hypertrophy, Left Ventricular / etiology, physiopathology*, ultrasonography Kidney Failure, Chronic / blood, complications, surgery*, therapy Kidney Transplantation* Male Middle Aged Peritoneal Dialysis Postoperative Care Potassium / blood Prospective Studies Renal Dialysis Stroke Volume Ventricular Function, Left / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 60-27-5/Creatinine; 7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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