Document Detail


Changes in left ventricular function and remodeling after myocardial infarction in hypothyroid rats.
MedLine Citation:
PMID:  19933415     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been shown that hypothyroidism may lead to delayed wound healing after experimental myocardial infarction (MI) in rats and increased infarct size in dogs. However, the long-term effect of hypothyroidism on left ventricular (LV) remodeling after MI has not been determined. Adult female Sprague-Dawley rats with and without surgical thyroidectomy (TX) were used in the study. Four weeks after TX, MI or sham MI was performed on TX and non-TX rats. Rats from all groups were examined 4 wk later. Four weeks after TX, hypothyroid-induced LV dysfunction was confirmed by echocardiography. In terminal experiments 4 wk after MI, TX sham-MI rats showed smaller hearts and impaired LV function compared with non-TX sham-MI controls. TX + MI rats showed smaller hearts with bigger infarct areas, higher LV end-diastolic pressures, and greater impairment of relaxation (-dP/dt) compared with non-TX MI rats. Relative changes after MI between TX and non-TX rats for most other hemodynamic and echocardiographic indexes were similar. These results suggest that preexisting hypothyroidism exaggerates post-MI remodeling and worsens LV function, particularly diastolic function.
Authors:
Yue-Feng Chen; Rebecca A Redetzke; Suleman Said; April J Beyer; A Martin Gerdes
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Publication Detail:
Type:  Journal Article     Date:  2009-11-20
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  298     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-18     Completed Date:  2010-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H259-62     Citation Subset:  IM    
Affiliation:
Cardiovascular Health Research Center, Sanford Research/University of South Dakota, Sioux Falls, SD 57105, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Atrophy
Body Weight / physiology
Female
Hemodynamics / physiology
Hypothyroidism / complications,  pathology*,  physiopathology*
Myocardial Infarction / complications,  pathology*,  physiopathology*
Myocardium / pathology
Organ Size / physiology
Rats
Rats, Sprague-Dawley
Thyroid Hormones / blood
Thyroidectomy
Ventricular Function, Left / physiology*
Ventricular Remodeling / physiology*
Chemical
Reg. No./Substance:
0/Thyroid Hormones

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