Document Detail

Changes in left ventricular diastolic function 6 months after nonsurgical septal reduction therapy for hypertrophic obstructive cardiomyopathy.
MedLine Citation:
PMID:  9918519     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Nonsurgical septal reduction therapy (NSRT) decreases left ventricular outflow tract (LVOT) gradient and improves symptoms in patients with hypertrophic obstructive cardiomyopathy (HOCM). NSRT effects on LV/left ventricular diastolic function are currently unknown. METHODS AND RESULTS: HOCM patients (n=29) had Doppler echocardiography at baseline and 6 months after NSRT to evaluate changes in LV volume, pre-A-wave pressure, early diastolic mitral annulus velocity (Ea) by tissue Doppler, and tau. At 6 months, a significant reduction in LVOT gradient (from 53.6+/-15 to 6+/-5 mm Hg; P<0.001) was accompanied by improvement in exercise duration (from 284+/-147 to 408+/-178 seconds; P=0.04) and New York Health Association class (from III to I; P<0.001). Pre-A pressure (18+/-6 to 14+/-5 mm Hg; P<0.01) and tau (62+/-8 to 51+/-8 ms; P<0.01) decreased, whereas Ea (5.8+/-1.8 to 8+/-1.8 cml/s; P<0.01) and LV end-diastolic volume (117+/-16 to 130+/-22 mL; P<0.01) increased. CONCLUSIONS: NSRT improves LV relaxation and compliance, which contributes to the symptomatic relief seen at 6 months.
S F Nagueh; N M Lakkis; K J Middleton; D Killip; W A Zoghbi; M A Quiñones; W H Spencer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation     Volume:  99     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-02-11     Completed Date:  1999-02-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  344-7     Citation Subset:  AIM; IM    
Department of Medicine, Cardiology Section, Baylor College of Medicine, Houston, Tex 77030, USA.
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MeSH Terms
Aged, 80 and over
Cardiomyopathy, Hypertrophic / physiopathology*,  therapy*,  ultrasonography
Diastole / physiology
Follow-Up Studies
Heart Septum / physiology
Middle Aged
Mitral Valve / physiology
Ventricular Function, Left / physiology*
Ventricular Outflow Obstruction / physiopathology*,  therapy,  ultrasonography

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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