| Changes in left thoracic duct lymph flow during progressive anemia in the ovine fetus. | |
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MedLine Citation:
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PMID: 9065113 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to evaluate the extent to which increased lymph flow can return fluid and protein to the circulation in the chronically anemic fetus. STUDY DESIGN: Thoracic duct lymph flow rate over a range of outflow pressures was measured in 8 near-term fetal sheep 4 to 5 days after surgery and daily thereafter for 5 days. After each day's study 60 to 150 ml of blood was withdrawn at a rate of 1 ml per minute. Regression analysis was used to establish the lymph flow function curve. Lymph and plasma protein concentrations and lymph flow rate were compared by analysis of variance for repeated measures. RESULTS: As the hematocrit was reduced from 34.6% +/- 1.3% (mean +/- SE) to 14.4% +/- 1.0%, thoracic duct lymph flow increased from 0.12 +/- 0.01 to 0.28 +/- 0.02 ml/min/kg. Plasma total protein concentration did not change, lymph protein concentration fell (2.6 +/- 0.1 to 2.4 +/- 0.1 gm/dl), and the difference between plasma and lymph protein concentrations increased (1.04 +/- 0.05 to 1.34 +/- 0.10 gm/dl). Protein returned to the circulation increased from 11.5 +/- 0.3 to 23.7 +/- 1.5 mg per minute. Central venous pressure did not change and remained less than the breakpoint pressure. Although the plateau lymph flow rate increased, neither the breakpoint or stopflow pressures of the lymph flow function curve were altered. CONCLUSIONS: Fetal lymph flow and thereby capillary filtration increased progressively as anemia became more severe. The increase in lymph flow did not appear to be limited by outflow pressure. By returning protein to the circulation, an increase in thoracic duct lymph flow helped to limit expansion of extravascular fluid volume during chronic fetal anemia. |
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Authors:
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L E Davis; A R Hohimer; R A Brace |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 174 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1996 May |
Date Detail:
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Created Date: 1997-03-17 Completed Date: 1997-03-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1469-76 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics, Oregon Health Sciences University, Portland 97201-3098, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anemia
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physiopathology* Animals Blood Proteins / analysis Fetal Blood Fetus / physiology* Hematocrit Hemodynamics Lymph / chemistry, physiology* Multivariate Analysis Proteins / analysis Sheep / embryology Thoracic Duct / physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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HD21269/HD/NICHD NIH HHS; R29HL45043/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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