Document Detail

Changes in the isolated delayed component as an endpoint of catheter ablation in arrhythmogenic right ventricular cardiomyopathy: predictor for long-term success.
MedLine Citation:
PMID:  18284499     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Although successful ablation of ventricular tachycardia (VT) is feasible in arrhythmogenic right ventricular cardiomyopathy (ARVC), long-term recurrence is common. The aim of this study was to assess the usefulness of a change in the isolated delayed component (IDC) as an endpoint of the catheter ablation in ARVC. METHODS AND RESULTS: Eighteen patients (48 +/- 11 years) with ARVC were studied. Detailed endocardial mapping of the right ventricle (RV) was performed during sinus rhythm. IDCs were recorded in 16 patients and the latest IDCs were related to the VT circuit. Catheter ablation was carried out in the areas with the IDCs. At the end of the session, the IDC was electrically dissociated in one, disappeared in five, exhibited second-degree block in one, was significantly delayed (>or=50 ms) in three, and remained unchanged in six. The change in the IDC was correlated with the change in the type II/III late potentials in the signal-averaged electrocardiography (ECG) and the inducibility of the clinical VT after the ablation. During a follow-up of 61 +/- 38 months, VT recurred in six. The patients with a changed IDC had a significantly lower VT recurrence than those with no IDC or an unchanged IDC (P < 0.02). CONCLUSION: In patients with ARVC, (1) the IDCs during sinus rhythm are related to the clinical VT and can be a target for the ablation, (2) a change in the IDC can be used as an endpoint, and (3) qualitative analyses of the serial signal-averaged ECGs may be useful for the long-term follow-up.
Akihiko Nogami; Aiko Sugiyasu; Hiroshi Tada; Kenji Kurosaki; Mihoko Sakamaki; Shinya Kowase; Yasushi Oginosawa; Shoichi Kubota; Tatsuya Usui; Shigeto Naito
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2008-02-13
Journal Detail:
Title:  Journal of cardiovascular electrophysiology     Volume:  19     ISSN:  1540-8167     ISO Abbreviation:  J. Cardiovasc. Electrophysiol.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-08-29     Completed Date:  2009-01-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9010756     Medline TA:  J Cardiovasc Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  681-8     Citation Subset:  IM    
Division of Cardiology, Yokohama Rosai Hospital, Yokohama, Japan.
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MeSH Terms
Cardiomyopathies / etiology*,  surgery*
Catheter Ablation / methods*
Electrocardiography / methods*
Longitudinal Studies
Middle Aged
Tachycardia, Ventricular / complications*,  surgery*
Treatment Outcome
Ventricular Dysfunction, Right / etiology*,  surgery*

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