Document Detail

Changes in intraocular pressures during laparoscopy: a comparison of propofol total intravenous anesthesia to desflurane-thiopental anesthesia.
MedLine Citation:
PMID:  23833850     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to examine intraocular pressure (IOP) changes during laparoscopic cholecystectomy performed under either desflurane-thiopental anesthesia or propofol total intravenous anesthesia (TIVA). 36 patients who will undergo elective laparoscopic cholecystectomy were enrolled in the study. The patients were randomly divided into one of two groups: desflurane (Group D, n=18) or propofol (Group P, n=18). All patients received fentanyl 2 micro/kg IV, and then breathed 100% oxygen for 3 minutes prior to induction of anesthesia. Anesthesia was induced by using thiopental 5 mg/kg IV in Group D and 2 mg/kg IV propofol in group P. Neuromuscular block was achieved with rocuronium 0.6 mg/kg IV. Anesthesia was maintained with desflurane 3-6% in group D and propofol infusion 5-10 mg/kg/h in group P. Desflurane and propofol concentrations were adjusted to maintain mean arterial pressure witihin 20% of the preinduction value. During anaesthesia, fractionated doses of fentanyl 0.5-1 micro g /kg IV and maintenance doses of muscle relaxants were used. In both groups, the the mixture 60% nitrous oxide and 40% oxygen was administered used. Arterial pressure, heart rate, ETCO2, SpO2 and IOP were recorded at the predefined time points. Creation of pneumoperitoneum resulted in a significant increase in IOP which remained elevated throughout the operation in both groups. Also, we recorded a similar IOP changes with both techniques except at five minutes after pneumoperitoneum in 15 degrees reverse Trendelenburg position during desflurane-thiopental anesthesia. In c6nclusion, desflurane-thiopental anesthesia maintains the IOP at least at similar levels compared to propofol TIVA anesthesia.
Arslan Onuk Asuman; Arslan Baris; Karsli Bilge; Selen Bozkurt; Bülbüler Nurullah; Kahraman Meliha; Celik Umit
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Middle East journal of anaesthesiology     Volume:  22     ISSN:  0544-0440     ISO Abbreviation:  Middle East J Anaesthesiol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-07-09     Completed Date:  2013-07-23     Revised Date:  2014-10-10    
Medline Journal Info:
Nlm Unique ID:  8604187     Medline TA:  Middle East J Anaesthesiol     Country:  Lebanon    
Other Details:
Languages:  eng     Pagination:  47-52     Citation Subset:  IM    
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MeSH Terms
Anesthesia, Intravenous
Anesthetics, Inhalation / pharmacology*
Anesthetics, Intravenous / pharmacology*
Intraocular Pressure / drug effects*
Isoflurane / administration & dosage,  analogs & derivatives*,  pharmacology
Middle Aged
Propofol / pharmacology*
Prospective Studies
Thiopental / administration & dosage,  pharmacology*
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 57041-67-5/desflurane; 76-75-5/Thiopental; CYS9AKD70P/Isoflurane; YI7VU623SF/Propofol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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