| Changes in intraerythrocyte content and transmembrane fluxes of sodium during salt loading in subjects with and without family history of hypertension. | |
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MedLine Citation:
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PMID: 6322533 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied 17 young normotensive men with family history of hypertension (H) in two generations (father and grandfather) and 17 age matched control subjects (C) with respect to intraerythrocyte sodium (IeNa), sodium influx, and rate of sodium efflux. The investigation was done during ordinary salt intake and after four week's salt load. H had a significantly higher IeNa (9.5 +/- 0.4 mmol/l) compared to C (8.2 +/- 0.3 mmol/l), p less than 0.01. After salt loading H decreased significantly to 8.1 +/- 0.3 mmol/l while C did not change significantly (7.6 +/- 0.3 mmol/l). There was no significant difference between H and C in Na influx either on normal or on high salt intake. The rate constant for Na efflux was significantly lower on normal salt intake in H (0.0038 +/- 0.0003 vs 0.0050 +/- 0.0004 min-1, p less than 0.05). High salt intake increased the efflux rate constant significantly in H (0.0048 +/- 0.0003 min-1, p less than 0.05), while control subjects showed no difference (0.0053 +/- 0.0004 min-1) compared to pre-salt conditions. Our results suggest that young men with heredity for hypertension have a higher intraerythrocyte Na-content secondary to a lower rate of Na efflux. The Na influx did not differ between the two groups probably indicating an unchanged permeability for sodium in subjects with a family history of hypertension. |
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Authors:
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H Herlitz; O Gudmundsson; O Jonsson; J Nauclér; G Berglund |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta medica Scandinavica. Supplementum Volume: 677 ISSN: 0365-463X ISO Abbreviation: Acta Med. Scand. Suppl. Publication Date: 1983 |
Date Detail:
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Created Date: 1984-04-24 Completed Date: 1984-04-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370331 Medline TA: Acta Med Scand Suppl Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 69-72 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Membrane Permeability Erythrocyte Membrane / metabolism Erythrocytes / metabolism* Humans Hypertension / genetics*, metabolism Ion Channels / metabolism* Male Sodium / metabolism* Sodium Chloride / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Ion Channels; 7440-23-5/Sodium; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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