Document Detail

Changes in intracellular pH close to term and their possible significance to labour.
MedLine Citation:
PMID:  8594535     Owner:  NLM     Status:  MEDLINE    
The contractile pattern of uterine smooth muscle is markedly altered by even modest manipulations of intracellular pH (pHi); an acidification can abolish contractions, while alkalinization increases contractility. As at the end of gestation the uterus changes from being relatively quiescent to highly contractile, we investigated whether pHi changes with pregnancy in women. Isolated tissue was loaded with the pH-sensitive fluorophore, carboxy-SNARF. We found a significant alkalinization over the last few weeks of pregnancy. Such an increase in pHi will increase contractility of the uterus, and may therefore contribute to the mechanisms ensuring strong and efficient contractions occur during labour.
J R Parratt; M J Taggart; S Wray
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  430     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-04-09     Completed Date:  1996-04-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  1012-4     Citation Subset:  IM    
The Physiological Laboratory, The University of Liverpool, PO Box 147, Liverpool L69 3BX, UK.
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MeSH Terms
Delivery, Obstetric*
Fluorescent Dyes
Hydrogen-Ion Concentration
Intracellular Membranes / metabolism*
Labor, Obstetric*
Myometrium / metabolism*
Pregnancy Trimester, Third
Uterine Contraction / physiology
Reg. No./Substance:
0/Benzopyrans; 0/Fluorescent Dyes; 0/Naphthols; 0/Rhodamines; 0/carboxy-seminaphthorhodaminefluoride

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