| Changes in the intestinal mucosal cell populations of German shepherd dogs fed diets containing different protein sources. | |
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MedLine Citation:
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PMID: 7771702 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sixteen German Shepherd Dogs from 4 litters were IgA-deficient on the basis of at least 1 of 2 serum IgA determinations, and all had small intestinal bacterial overgrowth, as documented by quantitated small intestinal bacterial culture in another study. These dogs were fed 2 diets that differed principally in their protein source (chicken vs beef, milk, and wheat). All dogs were fed each diet for 2 weeks before the study began. Next, all dogs were fed the chicken-based diet for 2 months. Then, half the dogs (group 1) were randomly assigned to continue eating the chicken-based diet, while the other half (group 2) ate a diet containing beef, milk, and wheat proteins. The small intestine was biopsied at the beginning of the study and after dogs had eaten the assigned diet for 2 and 4 months. At 2 months, group-2 dogs had more colonic mucosal mast cells, but this difference did not persist at 4 months. At the end of the study (ie, 4 months), although all dogs were clinically normal, group-2 dogs had significantly (P = 0.010) decreased numbers of jejunal villus plasma cells. However, these histologic changes were not considered clinically important. There were no significant differences in blood eosinophil counts, serum trypsin-like immunoreactivity, or cobalamin, folate, or IgA concentration. Clinical differences were not detected between the 2 groups, before or after the study. Changes were seen in serum IgM and IgG concentrations.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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J F Edwards; T W Fossum; M D Willard; N D Cohen; W B Patterson; D P Carey |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of veterinary research Volume: 56 ISSN: 0002-9645 ISO Abbreviation: Am. J. Vet. Res. Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-07-06 Completed Date: 1995-07-06 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375011 Medline TA: Am J Vet Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 340-8 Citation Subset: IM |
Affiliation:
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Department of Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station 77843, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Count / veterinary Dietary Proteins / administration & dosage, immunology, pharmacology* Dog Diseases / prevention & control Dogs / immunology* Female Inflammatory Bowel Diseases / prevention & control, veterinary Intestinal Mucosa / cytology*, immunology Male Statistics as Topic |
| Chemical | |
Reg. No./Substance:
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0/Dietary Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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