| Changes in interleukin-1β and 6 after hepatic microwave tissue ablation compared with radiofrequency, cryotherapy and surgical resections. | |
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MedLine Citation:
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PMID: 20887844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Cytokine changes after microwave tissue ablation (MTA) were compared with hepatic resection, cryotherapy (CRYO), and radiofrequency ablation (RFA). Cytokine production was measured at various ablation volumes for each modality and correlated with the transitional inflammatory zone produced by the ablation techniques. METHODS: Live rats underwent MTA, surgical resection, CRYO or RFA of 15%, 33%, or 66% of the total hepatic volume. Serum samples were collected preoperatively and at 1, 3, 6, 24, and 48 hours after surgery and analyzed for pro-inflammatory cytokines interleukin (IL)-1β and IL-6. RESULTS: Significantly higher levels of both cytokines were present after CRYO and RFA compared with MTA, hepatic resection, or controls (P < .001). All animals survived except those undergoing RFA or CRYO of 66% of the hepatic volume, which died within 6 hours. Transitional zones produced after RFA were larger than those after CRYO or MTA, but no correlation was present with the amount of cytokines. CONCLUSIONS: Large-volume MTA is associated with a significant decreased cytokine response and is well tolerated compared with RFA and CRYO. |
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Authors:
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Fateh Ahmad; Gianpiero Gravante; Neil Bhardwaj; Andrew Strickland; Rizwan Basit; Kevin West; Roberto Sorge; Ashley R Dennison; David M Lloyd |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: American journal of surgery Volume: 200 ISSN: 1879-1883 ISO Abbreviation: Am. J. Surg. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2010-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370473 Medline TA: Am J Surg Country: United States |
Other Details:
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Languages: eng Pagination: 500-6 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Hepatobiliary and Pancreatic Surgery, Leicester Royal Infirmary, Leicester, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers / blood Catheter Ablation / methods* Cryotherapy / methods* Disease Models, Animal Hepatectomy / methods* Inflammation / blood Interleukin-1beta / blood* Interleukin-6 / blood* Liver Diseases / blood, pathology, therapy* Male Microwaves / therapeutic use* Postoperative Period Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Interleukin-1beta; 0/Interleukin-6 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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