Document Detail


Changes in the interaction of resting-state neural networks from adolescence to adulthood.
MedLine Citation:
PMID:  19172655     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study examined how the mutual interactions of functionally integrated neural networks during resting-state fMRI differed between adolescence and adulthood. Independent component analysis (ICA) was used to identify functionally connected neural networks in 100 healthy participants aged 12-30 years. Hemodynamic timecourses that represented integrated neural network activity were analyzed with tools that quantified system "causal density" estimates, which indexed the proportion of significant Granger causality relationships among system nodes. Mutual influences among networks decreased with age, likely reflecting stronger within-network connectivity and more efficient between-network influences with greater development. Supplemental tests showed that this normative age-related reduction in causal density was accompanied by fewer significant connections to and from each network, regional increases in the strength of functional integration within networks, and age-related reductions in the strength of numerous specific system interactions. The latter included paths between lateral prefrontal-parietal circuits and "default mode" networks. These results contribute to an emerging understanding that activity in widely distributed networks thought to underlie complex cognition influences activity in other networks.
Authors:
Michael C Stevens; Godfrey D Pearlson; Vince D Calhoun
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human brain mapping     Volume:  30     ISSN:  1097-0193     ISO Abbreviation:  Hum Brain Mapp     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-16     Completed Date:  2009-09-28     Revised Date:  2014-06-02    
Medline Journal Info:
Nlm Unique ID:  9419065     Medline TA:  Hum Brain Mapp     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2356-66     Citation Subset:  IM    
Copyright Information:
(c) 2009 Wiley-Liss, Inc.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adolescent Development*
Adult
Aging
Brain / growth & development*,  physiology*
Child
Female
Humans
Magnetic Resonance Imaging
Male
Neural Pathways / growth & development,  physiology
Regression Analysis
Rest / physiology*
Young Adult
Grant Support
ID/Acronym/Agency:
K23 MH070036/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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