Document Detail


Changes in insulin response to glucose after exercise training in partially pancreatectomized rats.
MedLine Citation:
PMID:  2055837     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of exercise training on glucose-stimulated insulin secretion (GSIS) were studied in male Sprague-Dawley rats made mildly to severely diabetic by partial pancreatectomy. Exercise trained (10 wk treadmill; T) and untrained (Unt) rats were grouped according to posttraining fed-state hyperglycemia as follows: T less than 200 and Unt less than 200 (glucose concn less than 200 mg/dl), T 200-300 and Unt 200-300 (glucose concn 200-300 mg/dl), and T greater than 300 and Unt greater than 300 (glucose concn greater than 300 mg/dl). After exercise training, hyperglycemic glucose clamps were performed in awake rats by elevation of arterial blood glucose concentration 126 mg/dl above fasting basal levels for 90 min. Exercise training significantly increased muscle citrate synthase activity. Prevailing hyperglycemia was reduced during the 10-wk exercise training period in all T rats with fed-state glucose concentrations less than 300, and only 53% of Unt rats in these groups had reduced glycemia. GSIS was significantly higher in T less than 200 [2.4 +/- 0.7 (SD) ng/ml at 90 min] than in Unt less than 200 (1.5 +/- 0.3). A similar response was found for T 200-300 (1.1 +/- 0.3 ng/dl) vs. Unt 200-300 (0.7 +/- 0.1) but not T greater than 300 (0.36 +/- 0.2) vs Unt greater than 300 (0.44 +/- 0.05). Sham-operated control rats had insulin concentrations of 6.6 +/- 1.6 ng/ml at the 90th min of the clamp. Acute exercise reduced fed-state glycemia in rats with mild-to-moderate (less than 300 mg/dl) diabetes.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
P A Farrell; A L Caston; D Rodd
Related Documents :
1468317 - Prevention of type ii diabetes by physical training. epidemiological considerations and...
1284997 - Effects of tracer, volume, osmolarity and infection on fluid kinetics during capd.
3661057 - Lowering of serum t3 and rise in reverse t3 induced by glucagon infusion in anaesthetiz...
12750587 - Skeletal muscle glucose uptake response to exercise in trained and untrained men.
12757547 - Traceability of inbred and crossbred cinta senese pigs by evaluating the oxidative stress.
16249397 - Cognitive processes in criminal profile construction: a preliminary study.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  70     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-08-01     Completed Date:  1991-08-01     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1563-8     Citation Subset:  IM    
Affiliation:
Laboratory for Human Performance Research, Pennsylvania State University, University Park 16802.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Diabetes Mellitus, Experimental / physiopathology
Glucose / administration & dosage*
Hyperglycemia / physiopathology
Insulin / secretion*
Islets of Langerhans / physiology*
Male
Pancreatectomy
Physical Conditioning, Animal*
Physical Exertion / physiology
Rats
Rats, Inbred Strains
Grant Support
ID/Acronym/Agency:
NSS-2-507-RR07082-24/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Insulin; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Respiratory muscle coordination and diaphragm length during expiratory threshold loading.
Next Document:  Training-induced muscle adaptations: increased performance and oxygen consumption.