Document Detail


Changes in insulin receptors during oral contraception.
MedLine Citation:
PMID:  7451643     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Combined estrogen/progestagen oral contraceptives (OC) have been reported to be associated with a deterioration of glucose tolerance and a decrease in insulin sensitivity; thus, since it has been suggested that steroids affect insulin receptor properties, the influence of OC on insulin receptors was investigated. The study groups were composed of nine normal menstruating women (controls), nine pill users, and two healthy women on OC for the first time. Insulin receptors on monocytes were evaluated at 7-day intervals during the 28 days between menses. Insulin receptor concentration and/or affinity did not show any variation in pill users during the test period and did not differ from values observed in controls in the luteal phase; consequently, the insulin receptor concentration in pill users is lower than that during the follicular phase or in men. The physiological variation of insulin receptor concentration and the increase of receptor affinity in the midfollicular phase, which characterize the normal menstrual cycle, are therefore abolished by OC. This effect occurs rapidly because it was also evident in the two women on OC for the first time. No difference was observed in fasting blood glucose and serum immunoreactive insulin concentrations between control subjects and pill users. The present data appear to confirm that sex steroids affect the insulin receptor and lend further support to the concept that caution must be used in clinical studies of insulin receptors when women are included. In addition, the results suggest that insulin receptors may play a role in the glucose intolerance and insulin insensitivity which have been described in pill users.
Combined estrogen/progestagen (OC) oral contraceptives have been reported to be associated with a deterioration of glucose tolerance and a decrease in insulin sensitivity. Since it has been suggested that steroids affect insulin receptor properties, the influence of OCs on insulin receptors was investigated. The study groups were composed of 9 normally-menstruating women (controls), 9 pill users, and 2 healthy women on OCs for the 1st time. Insulin receptors on monocytes were evaluated at 7-day intervals during the 28 days between menses. Insulin receptor concentration and/or affinity did not show any variation in pill users during the test period and did not differ from values observed in controls in the luteal phase; consequently, the insulin receptor concentration in pill users is lower than that during the follicular phase or in men. The physiological variation of insulin receptor concentration and the increase of receptor affinity in the midfollicular phase, which characterize the normal menstrual cycle are therefore abolished by OCs. This effect occurs rapidly because it was also evident in the 2 women on OCs for the 1st time. No difference was observed in fasting blood glucose and serum immunoreactive insulin concentrations between control subjects and pill users. The present data appear to confirm that sex steroids affect the insulin receptor and lend further support to the concept that caution must be used in clinical studies of insulin receptors when women are included. In addition, the results suggest that insulin receptors may play a role in the glucose intolerance and insulin insensitivity which have been described in pill users.
Authors:
R De Pirro; F Forte; A Bertoli; A V Greco; R Lauro
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  52     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-03-27     Completed Date:  1981-03-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  29-33     Citation Subset:  AIM; IM; J    
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MeSH Terms
Descriptor/Qualifier:
Adult
Contraceptives, Oral / pharmacology*
Contraceptives, Oral, Combined / pharmacology*
Ethinyl Estradiol / pharmacology*
Female
Follicular Phase / drug effects
Humans
Male
Menstruation
Norgestrel / pharmacology*
Receptor, Insulin / drug effects*,  metabolism
Chemical
Reg. No./Substance:
0/Contraceptives, Oral; 0/Contraceptives, Oral, Combined; 57-63-6/Ethinyl Estradiol; 6533-00-2/Norgestrel; EC 2.7.10.1/Receptor, Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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