Document Detail


Changes in indices of airway hyperresponsiveness during one year of treatment with inhaled corticosteroids in patients with asthma.
MedLine Citation:
PMID:  11321683     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We analyzed the changes in indices of airway hyperresponsiveness, including hypersensitivity and hyperreactivity, during one year of treatment with inhaled corticosteroids. We then investigated on which of them the inhaled corticosteroids had a primary effect. Fifty outpatients with asthma were recruited and treated with inhaled beclomethasone dipropionate. They underwent bronchoprovocation tests on the initial visit and at 3, 6, and 12 months. The dose of methacholine required to produce a 20% fall in the forced expiratory volume in 1 second (PD20-FEV1) was measured to evaluate airway hypersensitivity. A relatively novel index, the percent change in the forced vital capacity (deltaFVC%) at the PD20-FEV1, was assessed as a marker of airway hyperreactivity. PD20-FEV1 and deltaFVC% were assumed to indicate the horizontal shift of the dose-response curve and the vertical change in the maximal response plateau, respectively. Log(PD20-FEV1) and deltaFVC% continued to improve throughout the year (p < 0.001 and p = 0.002, respectively). Log(PD20-FEV1) improved significantly at the 3-month evaluation (p < 0.001), and deltaFVC% improved at the 6-month evaluation (p = 0.012). Log(PD20-FEV1) had no or weak relationships with deltaFVC% at all evaluation points. In conclusion, inhaled corticosteroids continued not only to reverse the leftward shift of the curve, but also to restore the plateau. Furthermore, their effect was reflected primarily by the former rather than the latter: They should be followed separately to examine how much airway inflammation is reduced.
Authors:
T Oga; K Nishimura; M Tsukino; T Hajiro; A Ikeda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of asthma : official journal of the Association for the Care of Asthma     Volume:  38     ISSN:  0277-0903     ISO Abbreviation:  J Asthma     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-25     Completed Date:  2001-05-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8106454     Medline TA:  J Asthma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  133-9     Citation Subset:  IM    
Affiliation:
Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan. ogat@kuhp.kyoto-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Adolescent
Adult
Aged
Anti-Asthmatic Agents / administration & dosage*
Asthma / drug therapy*
Beclomethasone / administration & dosage*
Bronchial Hyperreactivity / diagnosis*
Female
Forced Expiratory Volume
Glucocorticoids / administration & dosage*
Humans
Male
Middle Aged
Peak Expiratory Flow Rate
Treatment Outcome
Vital Capacity
Chemical
Reg. No./Substance:
0/Anti-Asthmatic Agents; 0/Glucocorticoids; 4419-39-0/Beclomethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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