| Changes in immunomodulatory constituents of human milk in response to active infection in the nursing infant. | |
| | |
MedLine Citation:
|
PMID: 22258136 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Introduction:To investigate whether immunologic factors in breast milk change in response to nursing infants' infection.Results:Total CD45 leukocyte count dropped from 5,655 (median and interquartile range: 1,911; 16,871) in the acute phase to 2,122 (672; 6,819) cells/ml milk after recovery with macrophage count decreasing from 1,220 (236; 3,973) to 300 (122; 945) cells/ml. Tumor necrosis factor-α (TNFα) levels decreased from 3.66 ± 1.68 to 2.91 ± 1.51 pg/ml. The decrease in lactoferrin levels was of borderline statistical significance. Such differences were not recorded in samples of the controls. Interleukin-10 levels decreased in the sick infants' breast milk after recovery, but also in the healthy controls, requiring further investigation. Secretory immunoglobulin A levels did not change significantly in the study or control group.Discussion:During active infection in nursing infants, the total number of white blood cells, specifically the number of macrophages, and TNFα levels increase in their mothers' breast milk. These results may support the dynamic nature of the immune defense provided by breastfeeding sick infants.Methods:Breast milk from mothers of 31 infants, up to 3 months of age, who were hospitalized with fever, was sampled during active illness and recovery. Milk from mothers of 20 healthy infants served as controls. |
| | |
Authors:
|
Arieh Riskin; Meital Almog; Regina Peri; Katy Halasz; Isaac Srugo; Aharon Kessel |
Related Documents
:
|
3843746 - Chromosome studies in 3665 consecutive newborn children. 21710116 - Prematurity: influence on mother's locus of control. 20592416 - Population pharmacokinetic investigation of digoxin in japanese infants and young child... 12859126 - Sustained effects of high participation in an early intervention for low-birth-weight p... 9575666 - Death at sea: certain factors responsible for occupational hazard in polish seamen and ... 17239176 - Outcome of perinatal care for very preterm infants at 5 years of age: a comparison betw... |
Publication Detail:
|
Type: Journal Article Date: 2011-12-21 |
Journal Detail:
|
Title: Pediatric research Volume: 71 ISSN: 1530-0447 ISO Abbreviation: Pediatr. Res. Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-01-19 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
|
Languages: eng Pagination: 220-5 Citation Subset: IM |
Affiliation:
|
Department of Neonatology, Bnai Zion Medical Center, Haifa, Israel. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Birth outcomes associated with cannabis use before and during pregnancy.
Next Document: HDL level or HDL function as the primary target in preventive cardiology.