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Changes in human placental oxygenation during maternal hyperoxia as estimated by BOLD MRI.
MedLine Citation:
PMID:  23303592     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: The purpose of this study was to investigate changes in human placental oxygenation during maternal hyperoxia by using the non-invasive blood oxygen level dependent (BOLD) magnetic resonance imaging (MRI) technique. METHODS: Eight healthy pregnant women in gestational week 28 to 36 were included in the study. By using a facial mask maternal hyperoxia was induced for 5 minutes. The BOLD MRI scan was performed using a 1.5 Tesla system with the following parameters: repetition time=8000 ms, echo-time=50 ms and flip angle= 90. RESULTS: In the BOLD image the normoxic placenta appeared heterogeneous with darker areas located to the fetal side and brighter areas to the maternal side. During hyperoxia the placenta became brighter and the structure more homogeneous. The BOLD signal of the total placenta (ΔBOLD(tot) ) increased by 15.2 ± 3.2% (mean ± SD), (p<0.0001). The increase was predominantly seen in the dark areas in the fetal part of the placenta (ΔBOLD(fet) ) 32.1 ± 9.3% when compared to the bright areas in the maternal part (ΔBOLD(mat) ) 5.4 ± 3.5%. CONCLUSION: During hyperoxia placental oxygenation was increased predominantly in the darker areas. This finding and the anatomic location of the dark placental areas suggest that the darker areas represent the fetal circulation of the placenta. To our knowledge this is the first study that successfully visualizes changes in placental oxygenation by using the BOLD MRI technique.
Authors:
Sorensen Anne; Peters David; Fründ Ernst; Lingman Göran; Christiansen Ole; Uldbjerg Niels
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-10
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 ISUOG. Published by John Wiley & Sons, Ltd.
Affiliation:
Department of Obstetrics and Gynecology, Aalborg Hospital, Aarhus University Aalborg, Denmark.
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