| Changes in hepatic blood flow during whole body hyperthermia. | |
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MedLine Citation:
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PMID: 20146563 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Changes in blood flow distribution are important for heat dispersion and for supportive therapeutic strategies such as simultaneous whole body hyperthermia (WBH) and administration of chemotherapy. The aim of this clinical study was to determine changes in hepatic blood flow during WBH for the treatment of metastatic cancer. MATERIALS AND METHODS: This observational clinical study was part of a phase I/II feasibility study of WBH. WBH was induced using a radiant heat device. Hepatic blood flow was estimated using indocyanine green clearance measurements. The plasma disappearance rate of indocyanine green (PDR-ICG) was recorded in percent/min. We used an invasive thermo-dye-dilution technique to estimate hepatic blood flow, cardiac output, and volume status. Mean arterial blood pressure was also measured invasively. To determine the effects of hyperthermia the measurements were performed at defined temperature points. RESULTS: In 10 of 22 treatments the PDR-ICG fell below normal values during hyperthermia, which represented a significant fall in hepatic blood flow. Cardiac output, volume status, and mean arterial blood pressure did not differ between patients whose liver blood flow was reduced and those whose liver blood flow remained unchanged. CONCLUSIONS: We observed distinct reductions in hepatic blood flow during WBH, which suggested a significant redistribution of blood flow away from the core during WBH. This was not mirrored by global circulatory parameters. |
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Authors:
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Maria Deja; Olaf Ahlers; Martin Macguill; Peter Wust; Bert Hildebrandt; Hanno Riess; Thoralf Kerner |
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Publication Detail:
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Type: Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group Volume: 26 ISSN: 1464-5157 ISO Abbreviation: Int J Hyperthermia Publication Date: 2010 |
Date Detail:
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Created Date: 2010-02-11 Completed Date: 2010-04-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8508395 Medline TA: Int J Hyperthermia Country: England |
Other Details:
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Languages: eng Pagination: 95-100 Citation Subset: IM |
Affiliation:
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Department of Anaesthesiology and Intensive Care Medicine, Charite-Universit?tsmedizin Berlin, Germany. maria.deja@charite.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antineoplastic Agents / therapeutic use* Blood Pressure / physiology Coloring Agents / metabolism Combined Modality Therapy Female Hemodynamics / physiology Humans Hyperthermia, Induced* Indocyanine Green / metabolism Liver Circulation / physiology* Male Middle Aged Neoplasm Metastasis Neoplasms / pathology, therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Coloring Agents; 3599-32-4/Indocyanine Green |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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