| Changes in hemoglobin F levels in pregnant women unaffected by clinical fetomaternal hemorrhage. | |
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MedLine Citation:
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PMID: 23073220 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Complete automation of high-performance liquid chromatography (HPLC) for determination of hemoglobin F (%Hb F) and hemoglobin A1c (%Hb A1c) levels has made this procedure available in many clinical laboratories. However, the physiological changes in %Hb F during pregnancy and the effects of physiological and supraphysiological levels of %Hb A1c on measurement of %Hb F have not been studied extensively. METHODS: Simultaneous determination of %Hb F and %Hb A1c was conducted in 490 blood samples obtained before (n=21), during 1st (n=150), 2nd (n=116), and 3rd (n=192) trimesters of pregnancy, and postpartum (n=11) from 357 women, including 60 women with hyperglycemia but unaffected by clinical fetomaternal hemorrhage, by HPLC. RESULTS: Mean (SD) Hb F levels were 0.71% (0.25%) before pregnancy. The value of 0.82% (0.47%) during 1st trimester decreased significantly to 0.66% (0.35%) during 2nd trimester and to 0.58% (0.38%) during 3rd trimester. The level was 0.62% (0.31%) approximately one year after delivery. Thus, %Hb F was highest during 1st trimester of pregnancy. The effects of varied %Hb A1c levels on %Hb F measurements were clinically negligible. CONCLUSIONS: The data presented in this work may be used as reference intervals of %Hb F determined with HPLC during pregnancy. |
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Authors:
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Takashi Yamada; Mamoru Morikawa; Takahiro Yamada; Ryutaro Nishida; Masamitsu Takeda; Satoshi Kawaguchi; Hisanori Minakami |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-13 |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: - ISSN: 1873-3492 ISO Abbreviation: Clin. Chim. Acta Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Obstetrics, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan. Electronic address: amataka@med.hokudai.ac.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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