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Changes in hemoglobin F levels in pregnant women unaffected by clinical fetomaternal hemorrhage.
MedLine Citation:
PMID:  23073220     Owner:  NLM     Status:  Publisher    
BACKGROUND: Complete automation of high-performance liquid chromatography (HPLC) for determination of hemoglobin F (%Hb F) and hemoglobin A1c (%Hb A1c) levels has made this procedure available in many clinical laboratories. However, the physiological changes in %Hb F during pregnancy and the effects of physiological and supraphysiological levels of %Hb A1c on measurement of %Hb F have not been studied extensively. METHODS: Simultaneous determination of %Hb F and %Hb A1c was conducted in 490 blood samples obtained before (n=21), during 1st (n=150), 2nd (n=116), and 3rd (n=192) trimesters of pregnancy, and postpartum (n=11) from 357 women, including 60 women with hyperglycemia but unaffected by clinical fetomaternal hemorrhage, by HPLC. RESULTS: Mean (SD) Hb F levels were 0.71% (0.25%) before pregnancy. The value of 0.82% (0.47%) during 1st trimester decreased significantly to 0.66% (0.35%) during 2nd trimester and to 0.58% (0.38%) during 3rd trimester. The level was 0.62% (0.31%) approximately one year after delivery. Thus, %Hb F was highest during 1st trimester of pregnancy. The effects of varied %Hb A1c levels on %Hb F measurements were clinically negligible. CONCLUSIONS: The data presented in this work may be used as reference intervals of %Hb F determined with HPLC during pregnancy.
Takashi Yamada; Mamoru Morikawa; Takahiro Yamada; Ryutaro Nishida; Masamitsu Takeda; Satoshi Kawaguchi; Hisanori Minakami
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-13
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  -     ISSN:  1873-3492     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Department of Obstetrics, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan. Electronic address:
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