Document Detail

Changes in heart rate variability across different degrees of acute dilutional anemia.
MedLine Citation:
PMID:  21952593     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We investigated changes in heart rate variability (HRV) across different degrees of acute dilutional anemia (hemoglobin [Hb]=9, 7, 5, 4, and 3 g/dL) in a pig model.
METHODS: Twelve anesthetized mechanically ventilated pigs of either gender (mean body weight 27.5±5.5 kg) were hemodiluted by exchange of blood for hydroxyethyl starch (6%; 200000/0.5) from baseline values to each animal's individual critical hemoglobin concentration (Hbcrit 3.3 [2.3/3.6] g/dL). Differences in time- and frequency-domain calculations of HRV were analyzed throughout the hemodilution procedure by using short-term electrocardiogram recordings (analysis of variance+Dunn's post-hoc test).
RESULTS: During the hemodilution procedure, the standard deviation of normal R-R intervals and the coefficient of variation changed at Hb 5.3 (4.2/5.7) g/dL. Thereafter, the high-frequency power (HF), total power of the variance, and root mean square of successive N-N interval differences changed at Hb 3.9 (3.1/4.3) g/dL. The low-frequency power (LF) and the LF/HF ratio remained unaffected by hemodilution to Hbcrit.
CONCLUSION: Acute dilutional anemia resulted in significant changes in different time- and frequency-domain variables in HRV analysis. These changes occurred considerably earlier than did commonly recognized transfusion triggers or signs of general tissue hypoxia. Further investigation is warranted to elucidate whether these changes can be considered as indicators of imminent tissue hypoxia.
P Lauscher; H Kertscho; L Raab; O Habler; J Meier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Minerva anestesiologica     Volume:  77     ISSN:  1827-1596     ISO Abbreviation:  Minerva Anestesiol     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-28     Completed Date:  2012-01-16     Revised Date:  2012-06-05    
Medline Journal Info:
Nlm Unique ID:  0375272     Medline TA:  Minerva Anestesiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  943-51     Citation Subset:  IM    
Clinic of Anesthesiology, Intensive Care Medicine and Pain Therapy, Goethe-University Hospital Center, Frankfurt am Main, Germany.
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MeSH Terms
Anemia / etiology*,  physiopathology*
Blood Gas Analysis
Blood Volume
Heart Rate / physiology*
Hemoglobins / metabolism
Hetastarch / adverse effects
Monitoring, Physiologic
Plasma Substitutes / adverse effects*
Reg. No./Substance:
0/Hemoglobins; 0/Plasma Substitutes; 9005-27-0/Hetastarch
Comment In:
Minerva Anestesiol. 2012 May;78(5):626; author reply 627   [PMID:  22410470 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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