| Changes in heart rate variability in sevoflurane and nitrous oxide anesthesia: effects of respiration and depth of anesthesia. | |
| | |
MedLine Citation:
|
PMID: 12031752 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
STUDY OBJECTIVE: To quantify the effects of sevoflurane on autonomic nerve function by analyzing changes in heart rate (HR) variability in sevoflurane anesthesia; and to investigate the effects of anesthetic depth and apnea on HR variability. DESIGN: Prospective study. SETTING: Operating room (OR) of a university medical center. PATIENTS: 7 ASA physical status I and II patients scheduled for elective surgery. INTERVENTIONS: Patients were premedicated with ranitidine 150 mg. Anesthesia was induced with thiopental sodium 4 mg/kg intravenously (IV) and succinylcholine 1 mg/kg IV, and maintained with nitrous oxide (N(2)O) 67% and sevoflurane in oxygen. Patients were ventilated mechanically at a rate of 15 breaths/min. MEASUREMENTS: R-R interval of electrocardiography (ECG), electroencephalogram (EEG), noninvasive arterial blood pressure (BP), and end-tidal sevoflurane concentration were recorded. Measurements were performed 1) after patients arrived at the OR and were placed in the supine position, 2) a stable period after inhalation of 2% sevoflurane, and 3) following the appearance of an isoelectric EEG at a higher concentration of sevoflurane. At times 2) and 3), data were recorded during mechanical ventilation and during apnea. MAIN RESULTS: There were decreases in both the low-frequency (LF; 0.04 to 0.15 Hz) and high-frequency (HF; 0.15 to 0.4 Hz) components of HR variability during anesthesia compared with the awake state. HF decreased during apnea at 2% sevoflurane, but LF did not change. Neither LF nor HF changed in response to the absence or presence of respiration during isoelectric EEG. CONCLUSIONS: Autonomic nerve activity was attenuated by sevoflurane. Parasympathetic input to the heart by respiration was markedly suppressed following the appearance of isoelectric EEG. |
| | |
Authors:
|
Itsuo Nakatsuka; Ryoichi Ochiai; Junzo Takeda |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of clinical anesthesia Volume: 14 ISSN: 0952-8180 ISO Abbreviation: J Clin Anesth Publication Date: 2002 May |
Date Detail:
|
Created Date: 2002-05-28 Completed Date: 2002-12-18 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8812166 Medline TA: J Clin Anesth Country: United States |
Other Details:
|
Languages: eng Pagination: 196-200 Citation Subset: IM |
Affiliation:
|
Department of Anesthesiology, School of Medicine, Keio University, Tokyo, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Anesthesia* Anesthetics, Inhalation / pharmacology* Apnea / chemically induced Blood Pressure / drug effects Electroencephalography / drug effects Heart Rate / drug effects* Hospitals, University Humans Methyl Ethers / pharmacology* Nitrous Oxide / pharmacology* Operating Rooms Prospective Studies Reference Values Respiration / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Anesthetics, Inhalation; 0/Methyl Ethers; 10024-97-2/Nitrous Oxide; 28523-86-6/sevoflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pollution of the medical air at a university hospital in the metropolitan Tokyo area.
Next Document: Chiari I malformation in parturients.