Document Detail


Changes in growth hormone (GH) secretion and in growth during puberty.
MedLine Citation:
PMID:  2809099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During normal adolescent development in males testosterone induces the adolescent growth spurt, at least in part, by increasing GH production via an increase in the amplitude of the peaks of GH which are released, and not by increasing the frequency of GH pulses. Testosterone and estrogen administration at low or modest doses to individuals with the capacity to produce GH causes GH production and IGF-I levels to increase. Testosterone given to GHD patients does not increase either of these factors. In addition, there may be two actions for growth promotion by testosterone. One unequivocally results from an increase in GH production in the presence of low or modest levels of testosterone. A direct action on bone growth is probably present also, as reflected by the growth promoting effect of oxandrolone, a weak androgen, in boys with CDGA in the absence of increased GH production.
Authors:
R M Blizzard; P M Martha; J R Kerrigan; N Mauras; A D Rogol
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  12     ISSN:  0391-4097     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  1989  
Date Detail:
Created Date:  1989-12-20     Completed Date:  1989-12-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  65-8     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Virginia, Charlottesville.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Androgens / pharmacology,  physiology
Estrogens / pharmacology,  physiology
Female
Growth*
Growth Disorders / metabolism,  physiopathology
Growth Hormone / blood*,  deficiency
Humans
Male
Puberty / blood*,  physiology
Sexual Maturation / drug effects,  physiology
Turner Syndrome / metabolism,  physiopathology
Grant Support
ID/Acronym/Agency:
RR00841/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Androgens; 0/Estrogens; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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