Document Detail

Changes in glycosaminoglycan, galactosyltransferase-I, and sialyltransferase during rat liver regeneration.
MedLine Citation:
PMID:  11315766     Owner:  NLM     Status:  MEDLINE    
After partial hepatectomy, the liver is capable of complete restoration to its normal size. The extracellular matrix, which surrounds the cells, plays important roles in this regeneration. Glycosaminoglycans (GAGs), which are components of the extracellular matrix, interact with several other matrix components and growth factors, and are involved in hepatocyte growth. In this study, the content of heparan sulfate, a major GAG in rat liver, reached a minimum at 12 hours after partial hepatectomy. Galactosyltransferase-I activity, related to the synthesis of GAGs, and sialyltransferase activity, related to the synthesis of glycoconjugates, reached a minimum at 6 hours. The serum and liver contents of hyaluronic acid reached a maximum at 1 day and returned gradually to their preoperative levels. These results suggest that polysaccharide synthesis was decreased in the Golgi apparatus of hepatocytes at the beginning of regeneration, and that hyaluronic acid degradation decreased in the lysosomes of hepatocytes. The ability to synthesize polysaccharides recovered ahead of the ability to degrade hyaluronic acid. The changes in these GAGs with time in the early regeneration period might play an important role in organ regeneration.
H Matsuya; K Takagaki; S Yoshihara; K Ishido; M Sasaki; M Endo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  193     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-04-23     Completed Date:  2001-08-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  187-95     Citation Subset:  IM    
Department of Biochemistry, Hirosaki University School of Medicine, Japan.
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MeSH Terms
Chromatography, High Pressure Liquid
Electrophoresis, Gel, Two-Dimensional
Fluorescent Dyes
Galactosyltransferases / metabolism*
Glycosaminoglycans / metabolism*
Hyaluronic Acid / blood,  metabolism
Liver / enzymology*
Liver Regeneration / physiology*
Rats, Wistar
Sialyltransferases / metabolism*
Reg. No./Substance:
0/Fluorescent Dyes; 0/Glycosaminoglycans; 9004-61-9/Hyaluronic Acid; EC 2.4.1.-/Galactosyltransferases; EC 4-beta-galactosyltransferase; EC 2.4.99.-/Sialyltransferases

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