| Changes in glycosaminoglycan expression in the rat developing intestine. | |
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MedLine Citation:
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PMID: 1903087 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Synthesis of glycosaminoglycan (GAG) chains was studied in the developing rat intestine. Intestinal segments, taken at various developmental stages, were exposed to 3H-glucosamine and 35S-sulfate for 6 hours. The amounts of 3H-GAGs (total GAGs) and of 35S-GAGs (sulfated GAGs) showed a clear age-dependence, with a broad maximum in the fetal period when dramatic growth and morphogenesis occur. Characterization of individual GAG species indicated that hyaluronic acid (HA), heparan and chondroitin sulfate (HS and CS) synthesis was modified quantitatively or qualitatively during development: decrease of HA with age; production of undersulfated HS molecules during embryonic life; shift towards a lower hydrodynamic form of HA and HS molecules after birth. We postulate that these alterations are crucial in the elaboration of an age-related specific extracellular microenvironment allowing intestinal growth and differentiation. |
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Authors:
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F Bouziges; P Simon-Assmann; P Simo; M Kedinger |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell biology international reports Volume: 15 ISSN: 0309-1651 ISO Abbreviation: Cell Biol. Int. Rep. Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-06-19 Completed Date: 1991-06-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7708050 Medline TA: Cell Biol Int Rep Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 97-106 Citation Subset: IM |
Affiliation:
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INSERM Unité 61, Biologie Cellulaire et Physiopathologie Digestive, Strasbourg, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging Animals Chondroitin Sulfates / biosynthesis* Chromatography, Ion Exchange Glycosaminoglycans / biosynthesis* Heparitin Sulfate / biosynthesis* Hyaluronic Acid / biosynthesis* Jejunum / embryology, growth & development*, metabolism Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Glycosaminoglycans; 9004-61-9/Hyaluronic Acid; 9007-28-7/Chondroitin Sulfates; 9050-30-0/Heparitin Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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