Document Detail

Changes in glycosaminoglycan expression in the rat developing intestine.
MedLine Citation:
PMID:  1903087     Owner:  NLM     Status:  MEDLINE    
Synthesis of glycosaminoglycan (GAG) chains was studied in the developing rat intestine. Intestinal segments, taken at various developmental stages, were exposed to 3H-glucosamine and 35S-sulfate for 6 hours. The amounts of 3H-GAGs (total GAGs) and of 35S-GAGs (sulfated GAGs) showed a clear age-dependence, with a broad maximum in the fetal period when dramatic growth and morphogenesis occur. Characterization of individual GAG species indicated that hyaluronic acid (HA), heparan and chondroitin sulfate (HS and CS) synthesis was modified quantitatively or qualitatively during development: decrease of HA with age; production of undersulfated HS molecules during embryonic life; shift towards a lower hydrodynamic form of HA and HS molecules after birth. We postulate that these alterations are crucial in the elaboration of an age-related specific extracellular microenvironment allowing intestinal growth and differentiation.
F Bouziges; P Simon-Assmann; P Simo; M Kedinger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell biology international reports     Volume:  15     ISSN:  0309-1651     ISO Abbreviation:  Cell Biol. Int. Rep.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-06-19     Completed Date:  1991-06-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708050     Medline TA:  Cell Biol Int Rep     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  97-106     Citation Subset:  IM    
INSERM Unité 61, Biologie Cellulaire et Physiopathologie Digestive, Strasbourg, France.
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MeSH Terms
Chondroitin Sulfates / biosynthesis*
Chromatography, Ion Exchange
Glycosaminoglycans / biosynthesis*
Heparitin Sulfate / biosynthesis*
Hyaluronic Acid / biosynthesis*
Jejunum / embryology,  growth & development*,  metabolism
Rats, Inbred Strains
Reg. No./Substance:
0/Glycosaminoglycans; 9004-61-9/Hyaluronic Acid; 9007-28-7/Chondroitin Sulfates; 9050-30-0/Heparitin Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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