Document Detail

Changes in glucose metabolism from discrete regions of rat brain and its relationship to reproductive failure during experimental diabetes.
MedLine Citation:
PMID:  7891676     Owner:  NLM     Status:  MEDLINE    
This study reports the effects of alloxan induced diabetes on glucose metabolism enzymes viz. Hexokinase, Lactate dehydrogenase, and Glucose-6-phosphate dehydrogenase from discrete brain regions. Enzymes activity was assayed from hypothalamic areas such as medial preoptic area and median eminence-arcuate region which have gonadotropin releasing hormone cell bodies and their terminals, respectively and other brain regions like septum, amygdala, hippocampus, and thalamus. In all the areas studied, induction of diabetes resulted in a significant decrease in particulate bound HK activity, whereas soluble HK, LDH and G6PDH activity showed increase at 3, 8, 15 and 28 days intervals. Insulin treatment of diabetic rats led to recovery in enzyme activity. Blood glucose levels increased significantly after induction of diabetes and recovery was seen after insulin treatment. The present results suggest that altered cerebral glucose metabolism may also be responsible for reproductive failure observed in diabetic rats.
S S Lakhman; P Sharma; G Kaur; G Kaur
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  141     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-04-20     Completed Date:  1995-04-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  97-102     Citation Subset:  IM    
Department of Biotechnology, Guru Nanak Dev University, Amritsar, India.
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MeSH Terms
Brain / metabolism*
Diabetes Mellitus, Experimental / drug therapy,  metabolism,  physiopathology*
Glucose / metabolism*
Glucosephosphate Dehydrogenase / metabolism
Gonadotropin-Releasing Hormone / metabolism
Hexokinase / metabolism
Hypothalamo-Hypophyseal System / metabolism,  physiopathology
Insulin / therapeutic use
L-Lactate Dehydrogenase / metabolism
Ovary / physiopathology
Rats, Wistar
Reg. No./Substance:
11061-68-0/Insulin; 33515-09-2/Gonadotropin-Releasing Hormone; 50-71-5/Alloxan; 50-99-7/Glucose; EC Dehydrogenase; EC Dehydrogenase; EC

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