Document Detail

Changes in global left ventricular function by multidirectional strain assessment in heart failure patients undergoing cardiac resynchronization therapy.
MedLine Citation:
PMID:  19501328     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of this study was to evaluate the acute and late effects of cardiac resynchronization therapy (CRT) on multidirectional left ventricular (LV) strain assessed by two-dimensional speckle-tracking imaging and automated function imaging (AFI). METHODS: Multidirectional LV strain (global radial strain [GRS Avg], global circumferential strain [GCS Avg], and global longitudinal peak systolic strain [GLPSS Avg]) were measured in 141 patients with heart failure before CRT implantation, immediately afterward, and after 3 to 6 months of follow-up. Moreover, the acute effects on multidirectional LV strain were evaluated after interrupting CRT at follow-up. Response to CRT was defined as a decrease in LV end-systolic volume > or = 15%. RESULTS: Responders (57%) and nonresponders (43%) showed similar baseline values for GRS Avg, GCS Avg, and GLPSS Avg. At follow-up, significant improvement in multidirectional LV strain, combined with significant reverse LV remodeling and improvement in LV ejection fraction, was noted only in responders. Importantly, no significant changes in multidirectional LV strain were observed immediately after CRT device implantation or after device interruption at follow-up. CONCLUSIONS: Two-dimensional speckle-tracking imaging and AFI enable the quantification of multidirectional LV mechanics. Improvement in LV strain in the 3 orthogonal directions after CRT appears to be a long-term effect and is related to the extent of reverse LV remodeling after CRT.
Victoria Delgado; Claudia Ypenburg; Qing Zhang; Sjoerd A Mollema; Jeffrey Wing-Hong Fung; Martin J Schalij; Cheuk-Man Yu; Jeroen J Bax
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  22     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-08     Completed Date:  2009-08-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  688-94     Citation Subset:  IM    
Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands.
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MeSH Terms
Cardiac Pacing, Artificial / methods*
Echocardiography, Doppler / methods*
Elasticity Imaging Techniques / methods*
Heart Failure / prevention & control*,  ultrasonography*
Image Enhancement / methods
Image Interpretation, Computer-Assisted / methods
Middle Aged
Regression Analysis
Reproducibility of Results
Retrospective Studies
Sensitivity and Specificity
Treatment Outcome
Ventricular Dysfunction, Left / prevention & control*,  ultrasonography*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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