| Changes in the gene expression of C-myc and CD38 in HL-60 cells during differentiation induced by nicotinic acid-related compounds. | |
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MedLine Citation:
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PMID: 18323656 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Changes in gene expression levels of c-myc and CD38 were examined during the differentiation of HL-60 cells to granulocytes due to three nicotinic acid-related compounds. CD38 expression was increased by isonicotinic acid and all-trans-retinoic acid (ATRA). Nicotinamide and nicotinamide N-oxide drastically decreased c-myc expression, but isonicotinic acid had no effect, suggesting that these compounds differentiate HL-60 to granulocytes through different pathways. These results should provide useful information as to the mechanisms of cell differentiation. |
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Authors:
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Chieri Ida; Shin Ogata; Katsuzumi Okumura; Hiroshi Taguchi |
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Publication Detail:
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Type: Journal Article Date: 2008-03-07 |
Journal Detail:
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Title: Bioscience, biotechnology, and biochemistry Volume: 72 ISSN: 1347-6947 ISO Abbreviation: Biosci. Biotechnol. Biochem. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-24 Completed Date: 2008-05-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205717 Medline TA: Biosci Biotechnol Biochem Country: Japan |
Other Details:
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Languages: eng Pagination: 868-71 Citation Subset: IM |
Affiliation:
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Laboratory of Molecular and Cellular Biology, Graduate School of Bioresources, Mie University, Tsu, Mie 514-8507, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD38
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analysis,
genetics* Cell Differentiation / drug effects* Gene Expression Regulation / drug effects* Granulocytes / cytology HL-60 Cells Humans Myeloid Cells / cytology* Nicotinic Acids / pharmacology* Proto-Oncogene Proteins c-myc / analysis, genetics* Reverse Transcriptase Polymerase Chain Reaction |
| Chemical | |
Reg. No./Substance:
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0/MYC protein, human; 0/Nicotinic Acids; 0/Proto-Oncogene Proteins c-myc; EC 3.2.2.5/Antigens, CD38 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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