Document Detail

Changes in the gene expression of C-myc and CD38 in HL-60 cells during differentiation induced by nicotinic acid-related compounds.
MedLine Citation:
PMID:  18323656     Owner:  NLM     Status:  MEDLINE    
Changes in gene expression levels of c-myc and CD38 were examined during the differentiation of HL-60 cells to granulocytes due to three nicotinic acid-related compounds. CD38 expression was increased by isonicotinic acid and all-trans-retinoic acid (ATRA). Nicotinamide and nicotinamide N-oxide drastically decreased c-myc expression, but isonicotinic acid had no effect, suggesting that these compounds differentiate HL-60 to granulocytes through different pathways. These results should provide useful information as to the mechanisms of cell differentiation.
Chieri Ida; Shin Ogata; Katsuzumi Okumura; Hiroshi Taguchi
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Publication Detail:
Type:  Journal Article     Date:  2008-03-07
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  72     ISSN:  1347-6947     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-24     Completed Date:  2008-05-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  868-71     Citation Subset:  IM    
Laboratory of Molecular and Cellular Biology, Graduate School of Bioresources, Mie University, Tsu, Mie 514-8507, Japan.
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MeSH Terms
Antigens, CD38 / analysis,  genetics*
Cell Differentiation / drug effects*
Gene Expression Regulation / drug effects*
Granulocytes / cytology
HL-60 Cells
Myeloid Cells / cytology*
Nicotinic Acids / pharmacology*
Proto-Oncogene Proteins c-myc / analysis,  genetics*
Reverse Transcriptase Polymerase Chain Reaction
Reg. No./Substance:
0/MYC protein, human; 0/Nicotinic Acids; 0/Proto-Oncogene Proteins c-myc; EC, CD38

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