| Changes in gastric emptying in recipients of successful combined pancreas-kidney transplants. | |
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MedLine Citation:
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PMID: 1804583 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gastroparesis causes gastric emptying disorders in patients with chronic diabetes mellitus and it results from reduced smooth muscle contractility secondary to autonomic dysfunction. Today there has been little objective evidence of improvement in gastric emptying following correction of both uremia and diabetes by combined kidney-pancreas transplantation. We used gastrointestinal symptom scores, solid gastric emptying tests and electrogastrography to evaluate the effect of combined kidney-pancreas transplantation on gastric emptying in 8 uremic diabetic patients. The mean age of the patients was 40 years (range: 30-51 years) and the mean duration of diabetes was 24 years (range: 16-30 years). The patients had been on dialysis up to 24 months. The pretransplant A1 mean was 6.5 before improving to 4.3 after transplantation. All patients were receiving exogenous insulin. Our study data indicate that uremic diabetics have a high prevalence of symptomatic gastrointestinal dysfunction including abnormalities of gastric emptying and gastric electrical activity. Following transplantation, the gastrointestinal symptomatology improved significantly. Significant improvement in the rate of gastric emptying also correlated with improvement in the symptom complex. Gastric electrical activity also improved during the follow-up period. |
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Authors:
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A O Gaber; D Oxley; J Karas; S Cardoso; D Hathaway; M H Shokouh-Amiri; S L Jensen; T L Abell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Digestive diseases (Basel, Switzerland) Volume: 9 ISSN: 0257-2753 ISO Abbreviation: Dig Dis Publication Date: 1991 |
Date Detail:
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Created Date: 1992-05-06 Completed Date: 1992-05-06 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8701186 Medline TA: Dig Dis Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 437-43 Citation Subset: IM |
Affiliation:
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Department of Surgery (Division of Transplantation), University of Tennessee, Memphis. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Diabetes Mellitus, Type 1 / physiopathology, surgery* Diabetic Nephropathies / physiopathology, surgery* Follow-Up Studies Gastric Emptying / physiology* Humans Kidney Transplantation / physiology* Middle Aged Pancreas Transplantation / physiology* Postoperative Complications / physiopathology* Prospective Studies Uremia / physiopathology, surgery |
| Grant Support | |
ID/Acronym/Agency:
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RR00211-26/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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