Document Detail


Changes in gamma-aminobutyric acid release induced by topical administration of drugs affecting its metabolism and receptors: studies in freely moving guinea pigs with epidural cups.
MedLine Citation:
PMID:  1338898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of local application of drugs affecting gamma-aminobutyric acid metabolism and receptors on cortical aminoacid release has been investigated in freely-moving guinea pigs equipped with epidural cups. Topical treatment with gamma-aminobutyric acid reuptake and/or metabolism inhibitors (alone and in combination) produced a slow and progressive increase in cortical aminoacid release. The inhibition of gamma-aminobutyric acid-transaminase with ethanolamino-O-sulphate seemed to be a suitable procedure for enhancing the gamma-aminobutyric acid efflux without interfering with its autoreceptor-mediated negative feedback, tested with the gamma-aminobutyric acid agonist (+/-)baclofen and antagonist phaclofen. A substantial part of the gamma-aminobutyric acid outflowing from the cortex was of neuronal origin since tetrodotoxin halved the basal efflux in the presence of gamma-aminobutyric acid reuptake and/or metabolism inhibitors. These results, considered together, indicate that the epidural cup technique may be a useful approach to study changes in cortical gamma-aminobutyric acid release induced by drugs acting on gabaergic transmission and directly applied on the surface of the cortex.
Authors:
S Tanganelli; L Ferraro; C Bianchi; L Beani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurochemistry international     Volume:  21     ISSN:  0197-0186     ISO Abbreviation:  Neurochem. Int.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1993-06-24     Completed Date:  1993-06-24     Revised Date:  2010-03-22    
Medline Journal Info:
Nlm Unique ID:  8006959     Medline TA:  Neurochem Int     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  15-20     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, University of Ferrara, Italy.
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MeSH Terms
Descriptor/Qualifier:
4-Aminobutyrate Transaminase / antagonists & inhibitors,  metabolism
Animals
Anticonvulsants / pharmacology
Baclofen / analogs & derivatives,  pharmacology*
Calcium / pharmacology
Cerebral Cortex / drug effects,  metabolism*
Epidural Space
Ethanolamines / pharmacology*
Feedback
Female
Guinea Pigs
Kinetics
Male
Nipecotic Acids / pharmacology*
Norepinephrine / pharmacology
Receptors, GABA-A / drug effects,  metabolism*
Sodium / pharmacology
Tetrodotoxin / pharmacology
beta-Alanine / pharmacology*
gamma-Aminobutyric Acid / metabolism*
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0/Ethanolamines; 0/Nipecotic Acids; 0/Receptors, GABA-A; 107-95-9/beta-Alanine; 108351-35-5/phaclofen; 1134-47-0/Baclofen; 4368-28-9/Tetrodotoxin; 51-41-2/Norepinephrine; 56-12-2/gamma-Aminobutyric Acid; 7440-23-5/Sodium; 7440-70-2/Calcium; 85375-85-5/N-(4,4-diphenyl-3-butenyl)nipecotic acid; 926-39-6/ethanolamine O-sulfate; EC 2.6.1.19/4-Aminobutyrate Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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