| Changes in gamma-aminobutyric acid release induced by topical administration of drugs affecting its metabolism and receptors: studies in freely moving guinea pigs with epidural cups. | |
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MedLine Citation:
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PMID: 1338898 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of local application of drugs affecting gamma-aminobutyric acid metabolism and receptors on cortical aminoacid release has been investigated in freely-moving guinea pigs equipped with epidural cups. Topical treatment with gamma-aminobutyric acid reuptake and/or metabolism inhibitors (alone and in combination) produced a slow and progressive increase in cortical aminoacid release. The inhibition of gamma-aminobutyric acid-transaminase with ethanolamino-O-sulphate seemed to be a suitable procedure for enhancing the gamma-aminobutyric acid efflux without interfering with its autoreceptor-mediated negative feedback, tested with the gamma-aminobutyric acid agonist (+/-)baclofen and antagonist phaclofen. A substantial part of the gamma-aminobutyric acid outflowing from the cortex was of neuronal origin since tetrodotoxin halved the basal efflux in the presence of gamma-aminobutyric acid reuptake and/or metabolism inhibitors. These results, considered together, indicate that the epidural cup technique may be a useful approach to study changes in cortical gamma-aminobutyric acid release induced by drugs acting on gabaergic transmission and directly applied on the surface of the cortex. |
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Authors:
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S Tanganelli; L Ferraro; C Bianchi; L Beani |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurochemistry international Volume: 21 ISSN: 0197-0186 ISO Abbreviation: Neurochem. Int. Publication Date: 1992 Jul |
Date Detail:
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Created Date: 1993-06-24 Completed Date: 1993-06-24 Revised Date: 2010-03-22 |
Medline Journal Info:
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Nlm Unique ID: 8006959 Medline TA: Neurochem Int Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 15-20 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, University of Ferrara, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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4-Aminobutyrate Transaminase
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antagonists & inhibitors,
metabolism Animals Anticonvulsants / pharmacology Baclofen / analogs & derivatives, pharmacology* Calcium / pharmacology Cerebral Cortex / drug effects, metabolism* Epidural Space Ethanolamines / pharmacology* Feedback Female Guinea Pigs Kinetics Male Nipecotic Acids / pharmacology* Norepinephrine / pharmacology Receptors, GABA-A / drug effects, metabolism* Sodium / pharmacology Tetrodotoxin / pharmacology beta-Alanine / pharmacology* gamma-Aminobutyric Acid / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Ethanolamines; 0/Nipecotic Acids; 0/Receptors, GABA-A; 107-95-9/beta-Alanine; 108351-35-5/phaclofen; 1134-47-0/Baclofen; 4368-28-9/Tetrodotoxin; 51-41-2/Norepinephrine; 56-12-2/gamma-Aminobutyric Acid; 7440-23-5/Sodium; 7440-70-2/Calcium; 85375-85-5/N-(4,4-diphenyl-3-butenyl)nipecotic acid; 926-39-6/ethanolamine O-sulfate; EC 2.6.1.19/4-Aminobutyrate Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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