Document Detail

Changes in gait pattern as assessed by the GAITRite™ walkway system in MPS II patients undergoing enzyme replacement therapy.
MedLine Citation:
PMID:  19319660     Owner:  NLM     Status:  In-Data-Review    
Patients with MPS II often present with limitations to functional mobility. With the advent of enzyme replacement therapy (ERT), robust assessment tools are important to assess response to treatment. The aim of this study was to see if the GAITRite™ system (electronic pressure sensitive walkway) could identify any changes to gait pattern following commencement of ERT. Six boys with MPS type II were assessed at baseline and at intervals post commencing ERT. Four individual characteristics of gait were studied - velocity, cadence, step length and base of support. Changes in parameters for each individual could be analysed and be compared with age matched controls. The data generated from the GAITRite™ indicated all six boys had changes to their gait pattern. The most notable changes were in velocity, step length and base of support. The GAITRite™ was found to identify changes in gait parameters in this group of patients. It is an accessible way of providing both quantitative and qualitative analysis of gait in the clinical environment, and could potentially be used to monitor response to treatment. Larger studies are needed to corroborate our findings, as well as to establish the GAITRite™ as a monitoring tool.
M Wood; M A Cleary; L Alderson; A Vellodi
Publication Detail:
Type:  Journal Article     Date:  2009-03-25
Journal Detail:
Title:  Journal of inherited metabolic disease     Volume:  32 Suppl 1     ISSN:  1573-2665     ISO Abbreviation:  J. Inherit. Metab. Dis.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2012-12-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910918     Medline TA:  J Inherit Metab Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  127-35     Citation Subset:  IM    
Department of Physiotherapy, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, WC1N 3JH, UK,
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