Document Detail


Changes in fos expression in the rat brainstem after bilateral labyrinthectomy.
MedLine Citation:
PMID:  12403124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to elucidate the role of the vestibulocerebellar neural circuits during two-stage bilateral labyrinthectomy (BL) we examined Fos-like immunoreactive (-LIR) neurons as a marker of neural activation in the rat brainstem after BL and the projections of these neurons into the vestibulocerebellum using retrograde tracing and immunohistochemical techniques. Simultaneous BL did not show any Fos expression in the medial vestibular nucleus (MVe). However, with an interval of > 6 h between the two stages of BL, Fos-LIR neurons were induced in the ipsilateral (ipsi-) MVe of the side operated on second, partially projecting into the ipsi-vestibulocerebellum. A previous study demonstrated that some of the unilateral labyrinthectomy-induced Fos-LIR neurons in the ipsi-MVe projected into the ipsi-vestibulocerebellum and inhibited the contra-MVe neurons, resulting in the restoration of the right-left balance. Taken together with our present data, it is suggested that some of the labyrinthectomy-induced Fos expression in the ipsi-MVe is representative of a switch-on signal for the vestibulo-cerebello-vestibular inhibitory neural circuits, which remain turned off after symmetrical lesions such as simultaneous BL but are turned on after severe asymmetrical lesions in order to restore the balance.
Authors:
Tadashi Kitahara; Aya Nakagawa; Munehisa Fukushima; Arata Horii; Noriaki Takeda; Takeshi Kubo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta oto-laryngologica     Volume:  122     ISSN:  0001-6489     ISO Abbreviation:  Acta Otolaryngol.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-10-29     Completed Date:  2003-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370354     Medline TA:  Acta Otolaryngol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  620-6     Citation Subset:  IM    
Affiliation:
Department of Otolaryngology and Sensory Organ Surgery, Osaka University Graduate School of Medicine, Japan. tkitahara@ent.med.osaka-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Animals
Auditory Pathways
Brain Stem / cytology,  metabolism*,  physiology
Cell Count
Ear, Inner / physiology,  surgery*
Fluorescent Antibody Technique, Indirect
Hypoglossal Nerve / metabolism
Immunohistochemistry
Neurons, Afferent / metabolism
Nystagmus, Physiologic
Proto-Oncogene Proteins c-fos / metabolism*
Rats
Rats, Wistar
Vestibular Function Tests
Vestibular Nuclei / metabolism
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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