Document Detail

Changes in forebrain hexokinase activity after aortic baroreceptor denervation.
MedLine Citation:
PMID:  3740309     Owner:  NLM     Status:  MEDLINE    
Although forebrain structures have been implicated in both the development and maintenance of the elevated arterial pressure (AP) after aortic baroreceptor denervation, little is known about the location of central structures involved in the hypertensive process. In the present study, regions of the forebrain whose metabolic activity was altered after aortic baroreceptor denervation were functionally identified using hexokinase (HK) histochemistry in the rat. Three days after bilateral aortic depressor nerve (ADN) transection AP was significantly elevated compared with sham ADN-transected animals (143 +/- 1 and 122 +/- 2 mmHg, respectively). Significant increases in HK activity were observed in the magno- and parvocellular components of the paraventricular nucleus of the hypothalamus, supraoptic nucleus, nucleus circularis, median preoptic nucleus, subfornical organ, and central nucleus of the amygdala in the ADN-transected animals. These data have demonstrated that removal of aortic baroreceptor afferent inputs alters the activity of forebrain structures previously implicated in regulation of body fluid balance and AP and suggest that these structures are involved in the hypertensive process after ADN transection.
W E Turton; J Ciriello; F R Calaresu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  251     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R274-81     Citation Subset:  IM    
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MeSH Terms
Aorta / innervation*
Blood Pressure
Brain / enzymology*
Heart Rate
Hexokinase / metabolism*
Hypertension / enzymology
Pressoreceptors / physiology*
Rats, Inbred Strains
Tissue Distribution
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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