Document Detail


Changes in first-pass interstitial kinetics of DTPA in myocardium submitted to low-flow ischemia.
MedLine Citation:
PMID:  16304479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: This study aimed to determine the changes during ischemia in the myocardial first-pass kinetics of DTPA, an extracellular tracer that is currently used for assessing myocardial perfusion with magnetic resonance imaging (Magnevist). MATERIALS AND METHODS: Using an indicator-dilution technique, first-pass kinetics of DTPA were compared between normoxia (n=11) and low-flow ischemia (n=11) in isolated rabbit hearts perfused with red blood cell-enhanced perfusate. RESULTS: There was no difference between ischemia and normoxia in the interstitial extraction and clearance rates of DTPA. Interstitial distribution volume of DTPA was, however, lower in ischemia than in normoxia (in percent of myocardial volume: 15+/-11% vs 25+/-11%, P=0.02) as a result of a relationship with coronary flow (P<0.001). CONCLUSIONS: During low-flow myocardial ischemia, DTPA kinetics are unchanged, except for the interstitial distribution volume that is decreased, presumably because of the shrinkage of extracellular fluid. These kinetic properties are favorable for detecting myocardial ischemia at rest with magnetic resonance imaging.
Authors:
Fatiha Maskali; Adey Ayalew; Pierre-Yves Marie; Patrick Menu; Laurent Antunes; Paul-Michel Mertes; Faïez Zannad; Jean-Marc Gravier; Gilles Karcher; Alain Bertrand
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Investigative radiology     Volume:  40     ISSN:  0020-9996     ISO Abbreviation:  Invest Radiol     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-23     Completed Date:  2006-02-09     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  766-72     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, Unité mixte UHP-Inserm U684, and the Laboratory of Hematology and Physiology, Faculty of Pharmacy, University Henri Poincaré, Nancy, France. Fatiha.Maskali@medecine.uhp-nancy.fr
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MeSH Terms
Descriptor/Qualifier:
Animals
Computer Simulation
Contrast Media
Gadolinium DTPA / diagnostic use*,  pharmacokinetics*
Image Enhancement / methods*
Image Interpretation, Computer-Assisted / methods*
Kinetics
Magnetic Resonance Imaging / methods*
Male
Metabolic Clearance Rate
Models, Cardiovascular
Myocardial Ischemia / metabolism*,  pathology*
Rabbits
Reproducibility of Results
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Contrast Media; 80529-93-7/Gadolinium DTPA

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