| Changes in the fine structure of bone cells after the administration of parathyroid extract. | |
| | |
| Jump to Full Text | |
MedLine Citation:
|
PMID: 6033936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This paper describes the effect of parathyroid extract on the fine structure of bone cells in the proximal metaphysis of the tibia. The extract was given to rats intraperitoneally, in single or repeated doses of 1-14 units (USP) per gram body weight, over short or extended periods, and the tissue was examined between 6 and 26 hr after the commencement of injection. During this period, osteoblasts showed the greatest changes. Their mitochondria became swollen and contained dense granules; both rough- and smooth-surfaced vesicles were distended; ribosomes were separated from the membranes; and various dense bodies appeared in the cytoplasm. Osteocytes were similarly but less affected, and osteoclasts differed little from those in normal animals. Eventually after repeated injections, the fine structure of many of the cells was disrupted. These changes were accompanied by erosion of the bony trabeculae without any great increase in numbers of osteoclasts. It is possible that the alterations in fine structure were the result of damage to the cells by the parathyroid extract. However, since the extract did not seem to stimulate classical osteoclastic activity, the mitochondrial swelling and dense bodies could have been related to the removal of mineral and matrix, respectively. |
| | |
Authors:
|
D A Cameron; H A Paschall; R A Robinson |
Related Documents
:
|
22580906 - Development of cell lines from the cactophagous insect: cactoblastis cactorum (lepidopt... 21312246 - Nickel toxicity in embryos and larvae of the south american toad: effects on cell diffe... 2322536 - Halocyamines: novel antimicrobial tetrapeptide-like substances isolated from the hemocy... 22764126 - Lack of tir ubiquitylation contributes to enteropathogenic e. coli remaining extracellu... 2990646 - Role of superoxide and hydrogen peroxide in cell lysis during irradiation in vitro of e... 16726786 - A method for cultivating morphologically undifferentiated embryonic stem cells from por... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of cell biology Volume: 33 ISSN: 0021-9525 ISO Abbreviation: J. Cell Biol. Publication Date: 1967 Apr |
Date Detail:
|
Created Date: 1967-10-12 Completed Date: 1967-10-12 Revised Date: 2010-06-22 |
Medline Journal Info:
|
Nlm Unique ID: 0375356 Medline TA: J Cell Biol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1-14 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Calcification, Physiologic Cytoplasm / drug effects Cytoplasmic Granules / drug effects Membranes / drug effects Microscopy Microscopy, Electron Mitochondria / drug effects Osteoblasts / drug effects* Osteoclasts / drug effects Osteocytes / drug effects Parathyroid Hormone / administration & dosage*, pharmacology* Rats Ribosomes / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Parathyroid Hormone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
|
Journal Information Journal ID (nlm-ta): J Cell Biol ISSN: 0021-9525 ISSN: 1540-8140 Publisher: The Rockefeller University Press |
Article Information Download PDF  Copyright © 1967 by The Rockefeller University Press Received Day: 17 Month: 2 Year: 1966 Print publication date: Day: 1 Month: 4 Year: 1967 Volume: 33 Issue: 1 First Page: 1 Last Page: 14 ID: 2107294 PubMed Id: 6033936 |
| CHANGES IN THE FINE STRUCTURE OF BONE CELLS AFTER THE ADMINISTRATION OF PARATHYROID EXTRACT | |
| D. A. Cameron | |
| H. A. Paschall | |
| R. A. Robinson | |
| From the Department of Pathology, University of Sydney, New South Wales, Australia, and the Division of Orthopaedics, The Johns Hopkins School of Medicine, Baltimore, Maryland |
|
Article Categories:
|
|
Previous Document: Structural variations during mitosis in the chick embryo.
Next Document: Studies of spermatogenesis in the hepaticae. I. Ultrastructure of the vierergruppe in Marchantia.