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Changes in the fine structure of bone cells after the administration of parathyroid extract.
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MedLine Citation:
PMID:  6033936     Owner:  NLM     Status:  MEDLINE    
This paper describes the effect of parathyroid extract on the fine structure of bone cells in the proximal metaphysis of the tibia. The extract was given to rats intraperitoneally, in single or repeated doses of 1-14 units (USP) per gram body weight, over short or extended periods, and the tissue was examined between 6 and 26 hr after the commencement of injection. During this period, osteoblasts showed the greatest changes. Their mitochondria became swollen and contained dense granules; both rough- and smooth-surfaced vesicles were distended; ribosomes were separated from the membranes; and various dense bodies appeared in the cytoplasm. Osteocytes were similarly but less affected, and osteoclasts differed little from those in normal animals. Eventually after repeated injections, the fine structure of many of the cells was disrupted. These changes were accompanied by erosion of the bony trabeculae without any great increase in numbers of osteoclasts. It is possible that the alterations in fine structure were the result of damage to the cells by the parathyroid extract. However, since the extract did not seem to stimulate classical osteoclastic activity, the mitochondrial swelling and dense bodies could have been related to the removal of mineral and matrix, respectively.
D A Cameron; H A Paschall; R A Robinson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of cell biology     Volume:  33     ISSN:  0021-9525     ISO Abbreviation:  J. Cell Biol.     Publication Date:  1967 Apr 
Date Detail:
Created Date:  1967-10-12     Completed Date:  1967-10-12     Revised Date:  2010-06-22    
Medline Journal Info:
Nlm Unique ID:  0375356     Medline TA:  J Cell Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-14     Citation Subset:  IM    
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MeSH Terms
Calcification, Physiologic
Cytoplasm / drug effects
Cytoplasmic Granules / drug effects
Membranes / drug effects
Microscopy, Electron
Mitochondria / drug effects
Osteoblasts / drug effects*
Osteoclasts / drug effects
Osteocytes / drug effects
Parathyroid Hormone / administration & dosage*,  pharmacology*
Ribosomes / drug effects
Reg. No./Substance:
0/Parathyroid Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): J Cell Biol
ISSN: 0021-9525
ISSN: 1540-8140
Publisher: The Rockefeller University Press
Article Information
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Copyright © 1967 by The Rockefeller University Press
Received Day: 17 Month: 2 Year: 1966
Print publication date: Day: 1 Month: 4 Year: 1967
Volume: 33 Issue: 1
First Page: 1 Last Page: 14
ID: 2107294
PubMed Id: 6033936

D. A. Cameron
H. A. Paschall
R. A. Robinson
From the Department of Pathology, University of Sydney, New South Wales, Australia, and the Division of Orthopaedics, The Johns Hopkins School of Medicine, Baltimore, Maryland

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