| Changes in fibrinolytic activity after angiotensin II receptor blockade in therapy-resistant hypertensive patients. | |
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MedLine Citation:
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PMID: 17425665 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In hypertensive patients, the activated renin-angiotensin system induces a prothrombotic state resulting from imbalance between coagulation and fibrinolysis. Although blood pressure cannot be regulated in therapy-resistant hypertensive patients, they may still be responsive to medication that attenuates the renin-angiotensin system. OBJECTIVE: our objective was to study possible attenuating properties of angiotensin II type 1 receptor blockers (AT1RBs) on the prothrombotic state in therapy-resistant hypertensive patients, focusing on parameters of fibrinolysis and coagulation. Methods: Fourteen therapy-resistant hypertensive patients received AT1RB eprosartan infusion (45 and 150 microg kg(-1)) (study group), and 33 therapy-resistant hypertensive patients received saline (0.9%) infusion (control group) prior to renal angiography. Baseline values of parameters of coagulation and fibrinolysis were set at 1.00, and relative changes were calculated. RESULTS: Plasminogen activator inhibitor type 1 (PAI-1) antigen showed non-significant decreases in both the study group (arterial 1.00-0.45, venous 1.00-0.42) and control group (arterial 1.00-0.84, venous 1.00-0.88). PAI-1 activity significantly decreased in the study group (arterial 1.00-0.72, venous 1.00-0.71) and control group (arterial 1.00-0.83, venous 1.00-0.94). In the study group, tissue-type plasminogen activator (t-PA) antigen decreased significantly (arterial 1.00-0.62, venous 1.00-0.67), whereas t-PA activity significantly increased (arterial 1.00-6.15, venous 1.00-2.66). In the control group, t-PA antigen remained unchanged. No changes were observed in blood pressure during and after infusion of eprosartan. CONCLUSION: Therapy-resistant hypertensive patients show beneficial changes in fibrinolytic activity after infusion of a non-pressor dose of AT1RB. |
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Authors:
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A W J H Dielis; M Smid; H M H Spronk; A J H M Houben; K Hamulyák; A A Kroon; H Ten Cate; P W de Leeuw |
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Publication Detail:
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Type: Journal Article Date: 2007-04-09 |
Journal Detail:
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Title: Journal of thrombosis and haemostasis : JTH Volume: 5 ISSN: 1538-7933 ISO Abbreviation: J. Thromb. Haemost. Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-07-26 Completed Date: 2007-10-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101170508 Medline TA: J Thromb Haemost Country: England |
Other Details:
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Languages: eng Pagination: 1509-15 Citation Subset: IM |
Affiliation:
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Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acrylates
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pharmacology Adult Aged Angiotensin II Type 1 Receptor Blockers / pharmacology* Blood Coagulation / drug effects Case-Control Studies Drug Resistance Endothelial Cells / drug effects Female Fibrinolysis* / drug effects Humans Hypertension / blood*, drug therapy* Imidazoles / pharmacology Male Middle Aged Thiophenes / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Acrylates; 0/Angiotensin II Type 1 Receptor Blockers; 0/Imidazoles; 0/Thiophenes; 133040-01-4/eprosartan |
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