Document Detail

Changes in fibrinolytic activity after angiotensin II receptor blockade in therapy-resistant hypertensive patients.
MedLine Citation:
PMID:  17425665     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In hypertensive patients, the activated renin-angiotensin system induces a prothrombotic state resulting from imbalance between coagulation and fibrinolysis. Although blood pressure cannot be regulated in therapy-resistant hypertensive patients, they may still be responsive to medication that attenuates the renin-angiotensin system.
OBJECTIVE: our objective was to study possible attenuating properties of angiotensin II type 1 receptor blockers (AT1RBs) on the prothrombotic state in therapy-resistant hypertensive patients, focusing on parameters of fibrinolysis and coagulation.
METHODS: Fourteen therapy-resistant hypertensive patients received AT1RB eprosartan infusion (45 and 150 microg kg(-1)) (study group), and 33 therapy-resistant hypertensive patients received saline (0.9%) infusion (control group) prior to renal angiography. Baseline values of parameters of coagulation and fibrinolysis were set at 1.00, and relative changes were calculated.
RESULTS: Plasminogen activator inhibitor type 1 (PAI-1) antigen showed non-significant decreases in both the study group (arterial 1.00-0.45, venous 1.00-0.42) and control group (arterial 1.00-0.84, venous 1.00-0.88). PAI-1 activity significantly decreased in the study group (arterial 1.00-0.72, venous 1.00-0.71) and control group (arterial 1.00-0.83, venous 1.00-0.94). In the study group, tissue-type plasminogen activator (t-PA) antigen decreased significantly (arterial 1.00-0.62, venous 1.00-0.67), whereas t-PA activity significantly increased (arterial 1.00-6.15, venous 1.00-2.66). In the control group, t-PA antigen remained unchanged. No changes were observed in blood pressure during and after infusion of eprosartan.
CONCLUSION: Therapy-resistant hypertensive patients show beneficial changes in fibrinolytic activity after infusion of a non-pressor dose of AT1RB.
A W J H Dielis; M Smid; H M H Spronk; A J H M Houben; K Hamulyák; A A Kroon; H Ten Cate; P W de Leeuw
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Publication Detail:
Type:  Journal Article     Date:  2007-04-09
Journal Detail:
Title:  Journal of thrombosis and haemostasis : JTH     Volume:  5     ISSN:  1538-7933     ISO Abbreviation:  J. Thromb. Haemost.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-26     Completed Date:  2007-10-11     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  101170508     Medline TA:  J Thromb Haemost     Country:  England    
Other Details:
Languages:  eng     Pagination:  1509-15     Citation Subset:  IM    
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MeSH Terms
Acrylates / pharmacology
Angiotensin II Type 1 Receptor Blockers / pharmacology*
Blood Coagulation / drug effects
Case-Control Studies
Drug Resistance
Endothelial Cells / drug effects
Fibrinolysis* / drug effects
Hypertension / blood*,  drug therapy*
Imidazoles / pharmacology
Middle Aged
Thiophenes / pharmacology
Reg. No./Substance:
0/Acrylates; 0/Angiotensin II Type 1 Receptor Blockers; 0/Imidazoles; 0/Thiophenes; 133040-01-4/eprosartan

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