Document Detail

Changes in fetal organ flow during intrauterine mechanical ventilation with or without oxygen.
MedLine Citation:
PMID:  3351209     Owner:  NLM     Status:  MEDLINE    
To investigate whether the changes in circulation at birth are due to lung ventilation, changes in PaO2 or both we mechanically ventilated in utero the lungs of 10 fetal sheep (120-127 days of gestational age) five days after instrumentation under general anaesthesia. Electrocortical activity (ECoG), eye movements (EOG), electromyographic activity from diaphragm and posterior neck activity (EMG) and electrocardiogram (ECG) were recorded. Fetal catheters (artery and vein of the hindlimb, arteries of both forelimbs which in three occasions were advanced into the left ventricle, fetal trachea and amniotic cavity), and an endotracheal tube were placed. After recovery radioactive 15 mu microspheres (I125, Ce141, Sr85 and Sc46) were injected into the inferior vena cava or left ventricle during high voltage electrocortical activity before and after lung expansion with N2 and after expansion with O2 for two levels of PaO2. PaCO2 did not change. The percentage of spheres trapped in the lungs increased from 9.6% to 44% after expanding the lungs with N2 and to 90% when fetal PaO2 increased (P less than 0.001). Blood flow to different organs did not change during normoxic expansion but it decreased significantly to the brain (91 +/- 25 to 27 +/- 8 ml/min per 100g, [mean +/- SD]) placenta (160 +/- 57 to 54 +/- 33 ml/min/100g) and coronaries (239 +/- 91 to 117 +/- 60 ml/min per 100g) when PaO2 was increased. In conclusion fetal circulation responds to raised levels of PaO2 well before birth probably by a direct action of oxygen on the vessels.
C E Blanco; C B Martin; J Rankin; M Landauer; T Phernetton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of developmental physiology     Volume:  10     ISSN:  0141-9846     ISO Abbreviation:  J. Dev. Physiol.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-05-02     Completed Date:  1988-05-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910737     Medline TA:  J Dev Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  53-62     Citation Subset:  IM    
Department of Pediatrics, University Hospital, Maastricht, The Netherlands.
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MeSH Terms
Anoxia / physiopathology*
Blood Gas Analysis
Blood Pressure
Brain / blood supply
Coronary Circulation
Embryonic and Fetal Development*
Heart Rate, Fetal
Oxygen / physiology*
Regional Blood Flow*
Respiration, Artificial*
Vascular Resistance
Reg. No./Substance:

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