Document Detail

Changes in the feeding behavior of rats elicited by histamine infusion.
MedLine Citation:
PMID:  3237828     Owner:  NLM     Status:  MEDLINE    
In this study, we examined the effect of a putative neurotransmitter or a neuromodulator histamine (HA) on the feeding behavior to elucidate its physiological function in the central nervous system. Rats were implanted with a cannula into the suprachiasmatic nucleus through which HA was continuously infused for 200 hours with an Alzet osmotic minipump. The food intake was recorded automatically. This infusion resulted in decrease in food intake during the dark period and increase in it during the light period which contributed to the decrease in total food intake and increase in the percentage of food intake during the light period. Percentage of food intake during the light period is a good index of the amplitude of the circadian rhythm. Presumably, HA is concerned not only in the meal size, but also in the chronological aspect of the feeding behavior. The administration of H1-antagonist, pyrilamine, antagonized the HA induced increase in food intake during the light period. These findings suggest that continuous infusion of HA affected the feeding behavior which is possibly mediated through the H1-receptors in rat brain.
N Itowi; K Nagai; H Nakagawa; T Watanabe; H Wada
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiology & behavior     Volume:  44     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1988  
Date Detail:
Created Date:  1989-05-04     Completed Date:  1989-05-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  221-6     Citation Subset:  IM    
Department of Pharmacology II, Osaka University Medical School, Japan.
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MeSH Terms
Cimetidine / pharmacology
Circadian Rhythm / drug effects
Dose-Response Relationship, Drug
Feeding Behavior / drug effects*
Histamine / pharmacology*
Pyrilamine / pharmacology
Rats, Inbred Strains
Suprachiasmatic Nucleus / drug effects*
Reg. No./Substance:
51-45-6/Histamine; 51481-61-9/Cimetidine; 91-84-9/Pyrilamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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