Document Detail

Changes in feeding behavior after peripheral loperamide administration in rats.
MedLine Citation:
PMID:  22268026     Owner:  NLM     Status:  In-Data-Review    
Changes in the parameters of operant feeding behavior and body weight were studied in rats after intragastric administration of μ-opioid receptor agonist loperamide. Loperamide administration significantly suppressed foraging behavior in rats and reduced their body weight. Our findings suggest that peripheral loperamide administration, according to the hypothesis of reciprocal interactions between the central and peripheral parts of the endogenous opioid system, suppresses activity of central opioid mechanisms of feeding behavior organization. Changes in feeding behavior can appear due to disturbances in the mechanisms of assessment of food reward. We hypothesized that natural activation of μ-opioid receptors of the stomach with food-derived peptides can be associated with "sensory satiation" mechanism limiting excessive food intake.
Yu A Chumakova; V G Bashkatova; S K Sudakov
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  150     ISSN:  1573-8221     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2012-01-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng; rus     Pagination:  398-400     Citation Subset:  IM    
Laboratory of Physiology of Reinforcement, P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia.
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