| Changes in the fatty acid profiles of plasma lipid fractions induced by dietary nucleotides in infants born at term. | |
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MedLine Citation:
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PMID: 3409855 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to determine the polyunsaturated fatty acid (PUFA) composition of plasma lipid fractions in newborn infants fed human milk (HM), milk formula (MF) or nucleotide-supplemented milk formula (NMF) during the first month of life. Linoleic acid was increased in infants fed formulas in all plasma lipid fractions with respect to those fed HM. Plasma phospholipids in MF-fed infants had lower percentages of PUFA of both omega 6 and omega 3 series, namely arachidonic and docosahexaenoic acids, than those fed HM or NMF; the unsaturation index was decreased in infants fed MF as compared to those fed HM or NMF. Arachidonic acid showed a similar behaviour in plasma cholesteryl esters as in phospholipids. No changes for long chain PUFA among the groups studied were observed for plasma triglycerides and free fatty acids. These results support previous findings that dietary nucleotides are involved in the regulation of desaturation and elongation of linoleic and linolenic acid to their longer superior homologous fatty acids. We suggest that dietary nucleotides may reverse the partial inhibition of delta 5-desaturase caused by an excess of linoleic acid in the diet during early postnatal life. |
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Authors:
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A Gil; E Lozano; C De-Lucchi; J Maldonado; J A Molina; M Pita |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: European journal of clinical nutrition Volume: 42 ISSN: 0954-3007 ISO Abbreviation: Eur J Clin Nutr Publication Date: 1988 Jun |
Date Detail:
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Created Date: 1988-10-06 Completed Date: 1988-10-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8804070 Medline TA: Eur J Clin Nutr Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 473-81 Citation Subset: IM |
Affiliation:
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Research Department of Uniasa, Camino de Purchil, Granada, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Delivery, Obstetric Fatty Acids, Unsaturated / analysis* Female Food, Formulated* Humans Infant Food* Infant, Newborn / blood* Male Milk, Human* Nucleotides / administration & dosage* Phospholipids / blood* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Unsaturated; 0/Nucleotides; 0/Phospholipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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