Document Detail

Changes in exhaled breath condensate pH in healthy and asthmatic pregnant women.
MedLine Citation:
PMID:  23369006     Owner:  NLM     Status:  Publisher    
OBJECTIVE: Asthma is a common chronic disease complicating pregnancy with a risk for perinatal complications. Control of airway inflammation in asthmatic pregnancy improves pregnancy outcomes. Our aim was to evaluate exhaled breath condensate (EBC) pH, a non-invasive method for the assessment of asthmatic airway inflammation, in healthy and asthmatic pregnancy. DESIGN: Cross-sectional study. SETTING: Hungarian university clinics. POPULATION: 17 healthy pregnant, 21 asthmatic pregnant, 23 healthy non-pregnant and 22 asthmatic non-pregnant women. METHODS: EBC samples were collected using a portable condenser, EBC pH was measured after argon deareation. Main outcome measure. EBC pH. RESULTS: EBC pH (mean±SD) of healthy non-pregnant and asthmatic non-pregnant women was similar (7.75±0.27 vs. 7.54±0.57; p=0.118), probably indicating an optimal control of airway inflammation in asthmatics. On the other hand, EBC pH was higher in healthy pregnant compared to healthy non-pregnant women (8.02±0.43 vs. 7.75±0.27; p=0.017). Higher EBC pH accompanying healthy pregnancy was absent in asthmatic pregnant patients whose EBC pH was lower (7.65±0.38) than that of healthy pregnant women (p=0.006), and it was similar to asthmatic and healthy non-pregnant women's data (p=0.470 and p=0.300, respectively). EBC pH in asthmatic pregnancy correlated positively with birthweight (r=0.49, p=0.047) and negatively with forced vital capacity (r=0.45, p=0.039). EBC pH was not related to blood pH. CONCLUSIONS: EBC pH is higher in healthy but not in asthmatic pregnancy compared to healthy non-pregnant data, indicating that oxidative inflammatory processes induced by asthma may compromise the regulatory mechanisms causing alkaline pH in the airways during pregnancy. © 2013 The Authors Acta Obstetricia et Gynecologica Scandinavica © 2013 Nordic Federation of Societies of Obstetrics and Gynecology.
Noémi Eszes; András Bikov; Zsófia Lázár; Anikó Bohács; Veronika Müller; Balázs Stenczer; János Rigó; György Losonczy; Ildikó Horváth; Lilla Tamási
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-31
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  -     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-2-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 The Authors Acta Obstetricia et Gynecologica Scandinavica © 2013 Nordic Federation of Societies of Obstetrics and Gynecology.
Department of Pulmonology, Semmelweis University.
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