Document Detail


Changes in the enzyme pattern of the mammary gland of the lactating rat after hypophysectomy and weaning.
MedLine Citation:
PMID:  4382257     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The enzymes glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, phosphoglucomutase, UDP-glucose pyrophosphorylase, phosphofructokinase, ATP-citrate lyase and acetyl-CoA carboxylase have been assayed in rat mammary glands in various stages of involution after hypophysectomy and weaning. 2. After hypophysectomy all seven enzymes decline in activity over a 12-16hr. period but the extent of the decline varies, with acetyl-CoA carboxylase becoming almost totally inactive, ATP-citrate lyase and phosphofructokinase showing a large decrease, and the remaining enzymes a less marked decline. 3. Within 24hr. of removing the litter a change in the pattern of enzyme activity is found very similar to that after hypophysectomy. 4. The significance of these results is discussed in relation to the endocrine control of mammary gland metabolism and the mechanisms of involution.
Authors:
E A Jones
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  103     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1967 May 
Date Detail:
Created Date:  1967-10-04     Completed Date:  1967-10-04     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  420-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Glucosephosphate Dehydrogenase / biosynthesis*
Hypophysectomy
Kinetics
Lactation / physiology
Ligases / biosynthesis*
Lyases / biosynthesis*
Mammary Glands, Animal / enzymology*
NAD
NADP
Nucleotidyltransferases / biosynthesis*
Oxytocin / pharmacology
Phosphofructokinase-1 / biosynthesis*
Phosphoglucomutase / biosynthesis*
Phosphogluconate Dehydrogenase / biosynthesis*
Pituitary Gland / physiology*
Pregnancy
Rats
Spectrophotometry
Ultracentrifugation
Weaning*
Chemical
Reg. No./Substance:
50-56-6/Oxytocin; 53-59-8/NADP; 53-84-9/NAD; EC 1.1.1.43/Phosphogluconate Dehydrogenase; EC 1.1.1.49/Glucosephosphate Dehydrogenase; EC 2.7.1.11/Phosphofructokinase-1; EC 2.7.7.-/Nucleotidyltransferases; EC 4.-/Lyases; EC 5.4.2.2/Phosphoglucomutase; EC 6.-/Ligases
Comments/Corrections

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