| Changes in the enzyme pattern of the mammary gland of the lactating rat after hypophysectomy and weaning. | |
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MedLine Citation:
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PMID: 4382257 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The enzymes glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, phosphoglucomutase, UDP-glucose pyrophosphorylase, phosphofructokinase, ATP-citrate lyase and acetyl-CoA carboxylase have been assayed in rat mammary glands in various stages of involution after hypophysectomy and weaning. 2. After hypophysectomy all seven enzymes decline in activity over a 12-16hr. period but the extent of the decline varies, with acetyl-CoA carboxylase becoming almost totally inactive, ATP-citrate lyase and phosphofructokinase showing a large decrease, and the remaining enzymes a less marked decline. 3. Within 24hr. of removing the litter a change in the pattern of enzyme activity is found very similar to that after hypophysectomy. 4. The significance of these results is discussed in relation to the endocrine control of mammary gland metabolism and the mechanisms of involution. |
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Authors:
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E A Jones |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Biochemical journal Volume: 103 ISSN: 0264-6021 ISO Abbreviation: Biochem. J. Publication Date: 1967 May |
Date Detail:
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Created Date: 1967-10-04 Completed Date: 1967-10-04 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2984726R Medline TA: Biochem J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 420-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Glucosephosphate Dehydrogenase / biosynthesis* Hypophysectomy Kinetics Lactation / physiology Ligases / biosynthesis* Lyases / biosynthesis* Mammary Glands, Animal / enzymology* NAD NADP Nucleotidyltransferases / biosynthesis* Oxytocin / pharmacology Phosphofructokinase-1 / biosynthesis* Phosphoglucomutase / biosynthesis* Phosphogluconate Dehydrogenase / biosynthesis* Pituitary Gland / physiology* Pregnancy Rats Spectrophotometry Ultracentrifugation Weaning* |
| Chemical | |
Reg. No./Substance:
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50-56-6/Oxytocin; 53-59-8/NADP; 53-84-9/NAD; EC 1.1.1.43/Phosphogluconate Dehydrogenase; EC 1.1.1.49/Glucosephosphate Dehydrogenase; EC 2.7.1.11/Phosphofructokinase-1; EC 2.7.7.-/Nucleotidyltransferases; EC 4.-/Lyases; EC 5.4.2.2/Phosphoglucomutase; EC 6.-/Ligases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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