| Changes in endothelin receptor type B and neuronal nitric oxide synthase in puromycin aminonucleoside-induced nephrotic syndrome. | |
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MedLine Citation:
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PMID: 20827336 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The collecting duct endothelin (ET) system, which involves ET-1 and its two receptors, may play a role in the regulation of renal sodium in association with the nitric oxide synthase (NOS) system. We determined whether sodium retention is associated with changes in the endothelin and NOS systems at different stages (i.e., a sodium retaining stage and a compensatory stage) of nephrotic syndromes. On day 7 after puromycin aminonucleoside (PAN) injection, urinary sodium excretion was decreased, ascites had developed, and there was a positive sodium balance. ET-1 mRNA expression was increased in the inner medulla of the kidney, whereas protein expression of ET receptor type B (ET(B)R) was unchanged. The expression of neuronal NOS (nNOS) was decreased in the inner medulla. On day 14, urinary sodium excretion was unchanged compared with controls. The expression of ET(B)R increased, while nNOS expression in the inner medulla was comparable to controls. These findings suggest that decreased nNOS plays a role in the development of sodium retention in the nephrotic syndrome. Recovery of nNOS and increased renal ET(B)R synthesis may promote sodium excretion in later stages of the nephrotic syndrome (on day 14). |
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Authors:
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Eun Hui Bae; Soo Wan Kim |
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Publication Detail:
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Type: Journal Article Date: 2010-08-31 |
Journal Detail:
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Title: The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology Volume: 14 ISSN: 1226-4512 ISO Abbreviation: Korean J. Physiol. Pharmacol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-09-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709505 Medline TA: Korean J Physiol Pharmacol Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 223-8 Citation Subset: - |
Affiliation:
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Department of Internal Medicine, Chonnam National University Medical School, Gwangju 501-757, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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