| Changes in the endorphin and serotonin content of rat immune cells during adulthood following maternal exposure to ethanol during pregnancy and lactation. | |
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MedLine Citation:
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PMID: 16839857 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lactating and lactating/pregnant rat dams consumed either 3% (vol/vol) ethanol (as the sole source of fluid) between the 1st and 21st days after delivery or 15% (vol/vol) ethanol for 24h on the 3rd day after delivery. Offspring of ethanol-consuming dams were compared with offspring of untreated control dams. In other groups, offspring of mothers given 3% ethanol during pregnancy were also compared to untreated controls. When the offspring were 2 months of age, endorphin and serotonin contents of immune cells (lymphocytes, granulocytes and monocytes, mast cells of the peritoneal fluid, and lymphocytes of the thymus) were determined by hormone-specific antibodies and flow cytometric as well as confocal microscopic analysis. In rats exposed to ethanol through breast-feeding, endorphin content significantly decreased in thymic cells independent of the alcohol concentration (and duration) during treatment. Each type of peritoneal cell contained significantly more serotonin after 3% alcohol treatment. For the prenatally exposed offspring, serotonin content significantly decreased for both ethanol treatment conditions during pregnancy. Remarkably, one day of exposure to 15% ethanol on the third day of pregnancy was sufficient to induce this enduring change in serotonin content of immune cells of offspring. Considering that endorphin and serotonin are important immunomodulators, these alcohol-induced changes could produce enduring influences on immune function. |
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Authors:
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György Csaba; Péter Kovács; Eva Pállinger |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Alcohol (Fayetteville, N.Y.) Volume: 38 ISSN: 0741-8329 ISO Abbreviation: Alcohol Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-07-14 Completed Date: 2006-11-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502311 Medline TA: Alcohol Country: United States |
Other Details:
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Languages: eng Pagination: 111-6 Citation Subset: IM |
Affiliation:
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Department of Genetics, Cell and Immunobiology, Semmelweis University, H-1445 PO Box 370, Nagyvarad ter 4, Budapest, Hungary. csagyor@dgci.sote.hu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ascitic Fluid / cytology Endorphins / analysis* Ethanol / administration & dosage* Female Granulocytes / chemistry Immune System / cytology*, drug effects* Lactation* Lymphocytes / chemistry Mast Cells / chemistry Microscopy, Confocal Monocytes / chemistry Pregnancy Prenatal Exposure Delayed Effects Rats Rats, Wistar Serotonin / analysis* Thymus Gland / cytology |
| Chemical | |
Reg. No./Substance:
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0/Endorphins; 50-67-9/Serotonin; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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